Evidence map›Paper›PMID 41652634›Full record

ArticleExperimental hematology & oncology2026

Mutation rates in main tumour driver genes predict prognosis in patients with superficial spreading or nodular primary melanoma: results from the CARAMEL study by the Italian Melanoma Intergroup (IMI).

Maria Cristina Sini, Jerry Polesel, Sara Simi, Antonella Manca, Antonio Cossu, Giovanni Battista Maestrale, Daniela Massi, Giuseppe Palmieri, Maria Antonietta Pizzichetta, CARAMEL Study Group

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology & oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Cristina SiniUnit of Cancer Genetics, Institute of Genetic & Biomedical Research (IRGB), National Research Council (CNR), Sassari, 07100, Italy.
Jerry PoleselCancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Sara SimiSection of Pathology, Department of Health Sciences, University of Florence, Florence, Italy.
Antonella MancaUnit of Cancer Genetics, Institute of Genetic & Biomedical Research (IRGB), National Research Council (CNR), Sassari, 07100, Italy.
Antonio CossuPathology and Histology Unit, Department of Medicine, Surgery & Pharmacy, University of Sassari, Sassari, Italy.
Giovanni Battista MaestraleUnit of Cancer Genetics, Institute of Genetic & Biomedical Research (IRGB), National Research Council (CNR), Sassari, 07100, Italy.
Daniela MassiSection of Pathology, Department of Health Sciences, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0002-5688-5923
Giuseppe Palmieri *Unit of Cancer Genetics, Institute of Genetic & Biomedical Research (IRGB), National Research Council (CNR), Sassari, 07100, Italy. gpalmieri@yahoo.com.ORCID http://orcid.org/0000-0002-4350-2276
Maria Antonietta Pizzichetta *Department of Dermatology, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0002-4201-8490
CARAMEL Study Group

Funding

Associazione "I Colori di Francesco" 02/2023Italian Ministry of Health "Ricerca Corrente" FSNSardinian Regional Government (Regione Autonoma della Sardegna, RAS) Legge 7/2007
6 · The paper itself

Abstract

Superficial spreading melanoma (SSM) and nodular melanoma (NM) are the two histotypes that account for most cutaneous primary melanomas. We evaluated the mutational status for the genes underlying melanomagenesis among a series of SSMs and NMs from different Italian geographical areas. An increased number of mutated melanoma-driver genes was found to occur in both histological subtypes, with no specific mutational pattern distinctive for SSM and NM lesions, being significantly associated to shorter progression-free survival and poorer overall survival.

Indexed as

Mutational statusNodular melanoma (NM)Primary cutaneous melanomaPrognosisSuperficial spreading melanoma (SSM)

Identifiers

PMID41652634
PMCPMC12882120

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.