Evidence map›Paper›PMID 41652602›Full record

ArticleBMC chemistry2026

Green RP-HPLC method for estimation of trigonelline: AQbD based development, validation, and application to nanoformulations.

Pavithra Kothapalli, Manimaran Vasanthan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pavithra KothapalliDepartment of Pharmaceutics, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, SRM College of Pharmacy, Kattankulathur, Tamilnadu, 603203, India.
Manimaran VasanthanDepartment of Quality Assurance, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, SRM College of Pharmacy, Kattankulathur, Tamilnadu, 603203, India. manimarv@srmist.edu.in.ORCID http://orcid.org/0000-0003-2404-6268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trigonelline is an alkaloidal plant derived bioactive compound reported for its various pharmacological activities. Recent advances in the utilization of this compound in drug development have highlighted the importance of establishing a reproducible and efficient analytical method for estimating trigonelline (TRG) in both its pure form and formulated nano systems. Current research aims to develop and validate a green RP-HPLC method for estimating TRG by integrating Analytical Quality by Design (AQbD) with the principles of Green Analytical Chemistry. Optimization of the chromatographic conditions was done by employing a rotatable central composite design with amount of mobile phase and its flow rate selected as critical variables and tailing factor (T

Indexed as

AQbDForced degradation studiesGreenness assessmentNanoformulationsRP-HPLC methodTrigonelline quantificationValidation

Identifiers

PMID41652602
PMCPMC12949508

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.