Evidence map›Paper›PMID 41652591›Full record

ArticleVeterinary research2026

A recombinant adenoviral vector vaccine expressing the ORF2 capsid protein confers robust protection against chicken astrovirus infection.

Fanrun Meng, Ruiqi Li, Longying Ding, Zhuoyuan Wang, Xiaoyang Liu, Yuchen Song, Feng Lang, Liangyu Yang, Ziqiang Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fanrun MengCollege of Veterinary Medicine, Hebei Agricultural University, Baoding, 071001, China.
Ruiqi LiCollege of Veterinary Medicine, Shandong Agriculture University, No. 7, Panhe Street, Taishan District, Tai'an, 271017, China.
Longying DingCollege of Veterinary Medicine, Shandong Agriculture University, No. 7, Panhe Street, Taishan District, Tai'an, 271017, China.
Zhuoyuan WangCollege of Veterinary Medicine, Shandong Agriculture University, No. 7, Panhe Street, Taishan District, Tai'an, 271017, China.
Xiaoyang LiuCollege of Veterinary Medicine, Shandong Agriculture University, No. 7, Panhe Street, Taishan District, Tai'an, 271017, China.
Yuchen SongCollege of Veterinary Medicine, Shandong Agriculture University, No. 7, Panhe Street, Taishan District, Tai'an, 271017, China.
Feng LangQingdao Yebio Bioengineering Co, Qingdao, 266000, China.
Liangyu YangCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, 650500, China.
Ziqiang ChengCollege of Veterinary Medicine, Shandong Agriculture University, No. 7, Panhe Street, Taishan District, Tai'an, 271017, China. czqsd@126.com.

Funding

The Shandong Modern Agricultural Technology & Industry System No. SDAIT11-04The Shandong Science and Technology Development Project No. 2023CXGC010704TS Scholar Project No. Tstp20240819
6 · The paper itself

Abstract

Chicken astrovirus (CAstV), which causes enteritis, nephritis, and growth retardation syndrome, including white chicken syndrome (WCS), represents a significant global economic burden, with no available vaccine. Its fecal-oral transmission route underscores the need for mucosal immunity at intestinal entry sites, while human adenovirus type 5 (HAdV-5) vectors are highly efficient at targeting mucosal tissues. To develop and evaluate a novel recombinant adenovirus-vectored vaccine against CAstV, we used the HAdV-5 vector (AdMax system) to construct rAd5-CAstV-ORF2, which expresses the immunodominant CAstV ORF2 capsid protein. The ORF2 gene was seamlessly cloned into the shuttle plasmid (pcADV-EF1-mNeonGreen-CMV) and packaged into human embryonic kidney (HEK293T) cells. The rAd5-CAstV-ORF2 vaccine achieved a high titer (6.32 × 10

Indexed as

Astroviridae InfectionsAvastrovirusCapsid ProteinsChickensPoultry DiseasesViral VaccinesAdenoviridaeAnimalsGenetic VectorsHumansVaccines, SyntheticCapsid ProteinsVaccines, SyntheticViral Vaccinesanimal protection testCAstVHAdV-5immunization responseORF2 capsid proteinRAd5-CAstV-ORF2 vaccine

Identifiers

PMID41652591
PMCPMC12977891

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.