ArticleParasites & vectors2026
Efficacy of high doses of ivermectin-clorsulon in cattle on Glossina palpalis gambiensis survival and fecundity: implications for human and animal trypanosomoses control.
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTrypanosomoses are parasitic diseases caused by Trypanosoma protozoa transmitted by tsetse flies (Glossina spp.) to humans and animals. These diseases cause major health and economic disruptions in sub-Saharan Africa. Despite the development and wide implementation of control strategies, the disease burden remains high and complementary tools are needed. Ivermectin is an endectocide toxic to arthropods, including Glossina. The aim of this study was to test the efficacy of different doses of ivermectin administered to cattle on the survival and fecundity of Glossina palpalis gambiensis Vanderplank, 1949 in Burkina Faso.
methodsThis study compared the survival and fecundity of tsetse flies exposed to cattle treated with ivermectin-clorsulon (onefold veterinary therapeutic dose [TD; 0.2 mg/kg], twofold TD [2TD; 0.4 mg/kg], and fourfold TD [4TD; 0.8 mg/kg]) with those of flies exposed to control cattle (no treatment). Direct-skin blood-feeding experiments were performed at different days post-injection (DPI) (DPI: 1, 8, 15, 22, 29, and 36). The 30-day fly survival was analyzed using Kaplan-Meier curves and Cox proportional hazards models. Fecundity parameters were compared among treatments using generalized linear modeling (GLM). Time to first pupation was also measured.
resultsFly mortality differed significantly between treatments (χ
conclusionsIn our experiment, blood meals from cattle treated with an ivermectin-clorsulon formulation significantly reduced tsetse fly survival and fecundity, two key traits influencing vectorial capacity. Thus, treatment of domestic animals with the formulation has the potential to reduce trypanosomes transmission and improve both human and animal health in sub-Saharan Africa.
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