Trial reportBMC geriatrics2026
AIDE
Trial report in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesComorbid depression is highly prevalent in very old adults hospitalized for acute medical illness. We have previously shown that immediate intervention with cognitive behavioral therapy (CBT) effectively reduces symptoms of depression and anxiety. The present study examines the long-term course and the effect of delayed intervention.
designRandomized, controlled cross-over trial of group CBT. SETTING AND
participantsWe recruited in-patients of a geriatric university department ≥ 65 years with depression (Hospital Anxiety and Depression Scale HADS ≥ 7). Intervention took place after hospital discharge in a day care setting.
methodsPatients were randomized to an immediate active intervention group (II) or a waiting list control group with delayed intervention (DI). II patients were invited immediately after discharge to 10 to 15 weekly behavioral group therapy sessions. After 4 months (T1), DI patients switched to active intervention, while II were followed under control conditions. Final evaluation took place after 12 months (T2). Primary endpoint was improvement in HADS.
results56 patients (82.0 ± 6.2 years, HADS 18.8 ± 7.0) were randomized to II, 99 patients (81.9 ± 5.9 years, HADS 18.1 ± 8.3) to DI. II patients improved significantly at T1 (HADS 10.4 ± 5.2). Improvement was sustained under control conditions at T2 (11.9 ± 7.8). DI patients did not improve on waiting list (T1 22.9 ± 8.3), but after initiation of active treatment (T2 16.0 ± 8.5) (ANOVA: F = 3.75, p = 0.026). Concomitantly, functional parameters such as Barthel Index and Timed-Up-and-Go differed significantly between groups with better courses in DI patients. Among II patients, 4 (7.1%) deceased and 2 (3.6%) were newly admitted to a nursing home, among DI, 15 (15.2%) and 10 (10.1%) respectively. CONCLUSIONS AND IMPLICATIONS: Cognitive behavioral group therapy yields sustained improvement of depressive symptoms in very old geriatric patients, if administered in a multimodal approach immediately following hospitalization for acute medical illness. Concomitant with improvement of depressive symptoms, patients benefit in terms of functional status and medical outcome.
trial registrationwww.germanctr.de ; DRKS 00004728; February 12, 2013.
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