ReviewBMC pediatrics2026
Allograft-localized post-transplant lymphoproliferative disorder in a pediatric kidney transplant recipient: a case report and focused review.
Review in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPost-transplant lymphoproliferative disorder (PTLD) is a serious complication of pediatric kidney transplantation. PTLD confined to the kidney allograft is uncommon, and optimal management in this setting remains uncertain. CASE PRESENTATION: An eight-year-old boy with chronic kidney disease stage G5D due to posterior urethral valves developed monomorphic PTLD limited to the kidney allograft one year after deceased-donor kidney transplantation. Histopathology demonstrated high-grade B-cell lymphoma of the activated B-cell phenotype, with negative Epstein–Barr virus DNA and low-level cytomegalovirus DNA without evidence of end-organ disease. In the absence of systemic disease, a multidisciplinary team pursued a graft-preserving strategy rather than upfront nephrectomy, consisting of reduction of immunosuppression and rituximab-based chemoimmunotherapy with cyclophosphamide, prednisolone, and rituximab (CPR). Despite treatment-related cytopenias and transient hemodialysis, the patient achieved complete metabolic remission on PET-CT and remains disease-free with preserved graft function at five years of follow-up.
conclusionThis case demonstrates that graft-preserving, risk-adapted chemoimmunotherapy can achieve durable remission in selected pediatric patients with allograft-localized PTLD while maintaining long-term kidney allograft function.
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