SynthesisBMC geriatrics2026
Evidence gaps in the effects of exercise on SASP-Related biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Individualized Treatment Approaches for Obstructive Sleep Apnea in Older Adults: Beyond Continuous Positive Airway Pressure.Advances in geriatric medicine and research · 2026Article
- Mid-upper arm circumference and diabetes/prediabetes in children and adolescents: A cross-sectional study using NHANES data.Medicine · 2026Article
- Review
- Article
- Chronic Intermittent Hypoxia Promotes Macrophage Inflammation Through Reduction of Adipocyte‑Derived Adiponectin.Journal of inflammation research · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCellular senescence is a hallmark of aging, characterized by the secretion of proinflammatory factors known as the senescence-associated secretory phenotype (SASP). While physical exercise is proposed as a potential modulator of cellular aging, its effect on specific senescence biomarkers in older adults remains unclear.
methodsWe conducted a systematic review and meta-analysis following PRISMA guidelines (PROSPERO: CRD42024623676). Randomized controlled trials (RCTs) involving participants aged ≥ 60 years were included if they compared structured exercise interventions with control conditions and reported biomarkers of cellular senescence. A Bayesian meta-analysis was performed, and the risk of bias was assessed using the Cochrane RoB 2.0 tool.
resultsThree RCTs (n = 1447; age range 66–79; 64.2% female) met the inclusion criteria. Two were eligible for meta-analysis, focusing on SASP-related cytokines (CCL2, IL-6, IL-8, TNF-α). No statistically significant differences were observed between the exercise and control groups. One excluded study reported increased SIRT levels following resistance training, but these are not standard senescence markers. Notably, none of the included RCTs evaluated key upstream markers such as p16^INK4a^ or p21, highlighting a critical gap in current research.
conclusionsThis review found no conclusive evidence that exercise training affects canonical markers of cellular senescence in older adults. The biomarkers analyzed were limited to SASP-related cytokines, which reflect downstream inflammation rather than primary senescence regulation. Future studies should use standardized protocols to evaluate upstream markers such as p16^INK4a^ and p21 to better understand the impact of physical activity on cellular aging.
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