Trial reportSubstance use & addiction journal2026
Study Protocol for a Pain Self-Management Intervention to Reduce Pain and Improve MOUD Engagement in Primary Care: A Randomized Trial.
Trial report in Substance use & addiction journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
10 authors.
Funding
Abstract
Individuals with opioid misuse (OM) or opioid use disorder (OUD) frequently have co-occurring chronic pain (CP). Services for these chronic conditions are commonly siloed in specialty treatment programs with few empirically demonstrated integrated interventions for patients with OM/OUD+CP. This manuscript describes the Tailored Retention and Engagement for Effective-integrated Treatment of OUD and Pain (TREETOP) engagement clinical trial protocol testing the effectiveness of a pain self-management (PSM) intervention at improving outcomes for patients with OM/OUD+CP in the context of primary care settings. This is a multisite hybrid type-1 effectiveness-implementation clinical trial (n = 228) wherein stratified equal randomization is used to assign participants to either PSM or usual care. The PSM intervention is novel because it was tailored to patients with OM/OUD+CP and is delivered remotely by a trained interventionist over ten 1-hour sessions. All study activities are conducted virtually, and follow-up study visits occur at 3-, 6- and 9-months. Enhanced technology-based recruitment strategies are used to boost accrual. The primary outcome is reduction in pain interference (PROMIS SF v1.0-Pain Interference 4a) at 3-months and secondary outcomes include pain self-efficacy (PSEQ), medications for opioid use disorder engagement and illicit drug use (Modified ASI). The supplemental protocol provides in-depth information on the study design and methods. Implementation measures are specific to this trial, which are crucial for the understanding and advancement of the uptake of evidence-based practices into everyday care. As part of the HEAL initiative
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