ReviewMolecular neurobiology2026
Folic Acid Metabolism and Its Impact on Neurogenesis: Molecular Mechanisms and Therapeutic Potential.
Review in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Emerging roles of pterins as signaling molecules in bacteria.Biochemical Society transactions · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Folic acid (FA), a vital water-soluble B vitamin, is indispensable for the development and maintenance of the nervous system. By modulating one-carbon metabolism, FA critically influences DNA and RNA synthesis, methylation reactions, and cell division, thereby profoundly affecting neurogenesis. Neurogenesis, encompassing the proliferation, differentiation, and maturation of neural stem cells, is tightly regulated by FA through its role in DNA synthesis and methylation. Impaired neurogenesis is implicated in various neurological disorders, highlighting its critical role in cognitive function, brain homeostasis, and neural repair. Recent advances have elucidated the intricate link between FA metabolism and neurogenesis, revealing potential therapeutic targets. Here, we provide a comprehensive review of the molecular mechanisms underlying FA's regulation of neurogenesis, focusing on its impact on epigenetic regulation and signaling pathways. We also discuss the interplay between folate metabolism, neurogenesis, and systemic diseases, emphasizing the translational potential of targeting FA metabolism in neurological disorders. Understanding these mechanisms is crucial for advancing fundamental neuroscience and developing novel therapeutic strategies for neurodevelopmental and neurodegenerative diseases. Future research should focus on elucidating the specific molecular pathways and potential therapeutic applications of FA in neurogenesis.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.