Evidence map›Paper›PMID 41652285›Full record

SynthesisJournal of assisted reproduction and genetics2026

Efficacy of dual triggering in poor ovarian responders defined according to Bologna and POSEIDON criteria: a systematic review with meta-analysis.

Antonio Mercorio, Alessandro Conforti, Nicola Pluchino, Panagiotis Drakopoulos, Matteo Giudice, Pierluigi Giampaolino, Alexandre Vallee, Vehbi Yavuz Tokgoz, Carlo Alviggi, Jean Marc Ayoubi

Erratum issuedAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Antonio MercorioAssisted Reproductive Technology Unit, Department of Gynecology, Hôpital Foch, Suresnes, France. antoniomercorio@gmail.com.
Alessandro ConfortiDepartment of Neurosciences, University of Naples Federico II, Naples, Italy.
Nicola PluchinoDivision of Gynecology, Department Woman-Mother-Child, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital of Lausanne, Lausanne, Switzerland.
Panagiotis DrakopoulosInstitute of Life, IVF Unit, Athens, Greece.
Matteo GiudiceDepartment of Neurosciences, University of Naples Federico II, Naples, Italy.
Pierluigi GiampaolinoDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Alexandre ValleeDepartment of Epidemiology-Data-Biostatistics, Delegation of Clinical Research and Innovation (DRCI), Foch Hospital, Suresnes, 92150, France.
Vehbi Yavuz TokgozReproductive Endocrinology and Infertility Unit, Department of Obstetrics and Gynecology, School of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey.
Carlo AlviggiDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Jean Marc AyoubiAssisted Reproductive Technology Unit, Department of Gynecology, Hôpital Foch, Suresnes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare dual triggering versus hCG-only triggering in poor responders undergoing controlled ovarian stimulation with a GnRH antagonist protocol in ART cycles.

methodsA systematic review and meta-analysis was performed. The primary outcome was the number of mature oocytes (MII). The number of oocytes retrieved, clinical pregnancy, and miscarriage rates were analyzed as secondary outcomes. Subgroup analyses were conducted according to the Bologna and POSEIDON classifications.

resultsTen studies were included. Dual triggering significantly increased the number of retrieved and mature oocytes in patients classified according to the Bologna criteria, but not in those classified by the POSEIDON criteria. Age-related differences across studies appeared to influence the efficacy of dual triggering. A borderline improvement in clinical pregnancy rates was observed among Bologna-defined patients. Miscarriage rates did not differ significantly between the groups.

conclusionsDual triggering appears to improve oocyte yield and maturity in Bologna-defined patients, but this effect is unlikely to apply uniformly across all phenotypes. Persistent heterogeneity in poor responder definitions limits the understanding of the benefits of dual triggering in this population. Well-designed prospective studies with rigorous phenotypic stratification are warranted to identify which patients are most likely to benefit from dual triggering.

Indexed as

Fertilization in VitroGonadotropin-Releasing HormoneOocytesOvulation InductionAbortion, SpontaneousChorionic GonadotropinFemaleHumansOocyte RetrievalPregnancyPregnancy RateChorionic GonadotropinGonadotropin-Releasing HormoneARTDual triggeringIVFOvarian stimulation, Poor ovarian respondersOvulation induction

Identifiers

PMID41652285
PMCPMC13103112

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.