Trial reportEuropean journal of pediatrics2026
Deferred cord clamping (DCC) at 1 min versus 3 min in preterm neonates - an open label randomized, controlled trial.
Trial report in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Deferred cord clamping (DCC) is the recommended method of placental transfusion for newborns who are vigorous at birth irrespective of gestational age. But there is lack of uniformity regarding the timing of DCC. The purpose of this study was to determine the effect of DCC for 3 min as compared to DCC for 1 min on clinically relevant hematological and hemodynamic parameters in preterm neonates. The primary outcome evaluated was venous hematocrit (Hct) at 48 (± 4) hrs of postnatal age. The important secondary outcomes assessed were mean blood pressure during the transitional period, venous Hct and ferritin levels at 6 weeks of age and significant neonatal morbidities. Three hundred and four (304) neonates of 30- 36
conclusionDelaying the clamping of cord for 3 min improves blood pressure and results in higher venous hematocrit in the initial transitional phase and beyond. DCC for 3 min may be a feasible and useful placental transfusion technique in the preterm population. Larger multicentric studies are required to confirm its efficacy and safety.
trial registrationCTRI/2024/10/075751; registration date October 23, 2024. WHAT IS KNOWN: • DCC is universally recommended for vigorous neonates at birth but no consensus exist for its duration. • Studies on the effective duration of DCC are scarce in the preterm population. WHAT IS NEW: • Delaying clamping of cord for 3 min is an effective placental transfusion strategy in preterm neonates of 30- 36 6/7 weeks gestation • DCC for 3 min can be an important strategy especially in developing countries where baseline prevalence of anemia is high.
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