Evidence map›Paper›PMID 41652204›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Recurrent respiratory papillomatosis: is patient well-being related to anatomical manifestation?

Constantia J M A Trimbos, Carlijn E L Hoekstra, Rico N P M Rinkel, Christine D L van Gogh, Birgit I Lissenberg, Michelle J Mallinger, Frederik G Dikkers

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Constantia J M A TrimbosDepartment of Otorhinolaryngology, Head and Neck Surgery, Amsterdam UMC location VU University Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. c.j.m.a.trimbos@amsterdamumc.nl.ORCID http://orcid.org/0009-0003-8343-3572
Carlijn E L HoekstraDepartment of Otorhinolaryngology, Head and Neck Surgery, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Rico N P M RinkelDepartment of Otorhinolaryngology, Head and Neck Surgery, Amsterdam UMC location VU University Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Christine D L van GoghDepartment of Otorhinolaryngology, Head and Neck Surgery, Amsterdam UMC location VU University Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Birgit I LissenbergDepartment of Epidemiology and Data Science, Amsterdam UMC location VU University Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Michelle J MallingerDepartment of Otorhinolaryngology, OLVG, Jan Tooropstraat 164, Amsterdam, 1061 AE, The Netherlands.
Frederik G DikkersDepartment of Otorhinolaryngology, Head and Neck Surgery, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo date, there is no uniform staging system to quantify the extent of recurrent respiratory papillomatosis (RRP). In scientific research on RRP, patient factor has not been leading in developing its potential staging system. Therefore, this report investigated the association between objective anatomical measurement and Patient Reported Outcome Measures (PROMs).

methodsThe extent of RRP was determined according to the Derkay score. Images from RRP patients were retrieved from laryngoscopic examinations (during phonation and respiration). Four laryngologists assigned Derkay scores independently. The RRP-specific Distress Thermometer & Problem List (DT&PL) was used as PROM. Derkay scores were compared to DT&PL scores using a linear mixed model.

resultsEighty-eight pairs of images were studied. The linear mixed model analysis resulted in a regression coefficient of 0.54 (P < 0.001, 95% CI 0.28–0.80). The average inter-observer class correlation coefficient was 0.95 (95% CI 0.93–0.96).

conclusionA moderate association was found between Derkay and DT&PL scores. Considering that RRP is a benign lesion, proper reflection of patient complaints is essential when staging the condition. Future research should consider the significance of the patient’s quality of life to develop a definitive staging method for clinical practice.

Indexed as

Papillomavirus InfectionsPatient Reported Outcome MeasuresRespiratory Tract InfectionsAdultAgedFemaleHumansLaryngoscopyMaleMiddle AgedQuality of LifeDerkay scorePROMRecurrent respiratory papillomatosisRRP

Identifiers

PMID41652204
PMCPMC13053424

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