Evidence map›Paper›PMID 41652187›Full record

ArticleCell death and differentiation2026

USP30 senses serine/glycine levels to regulate serine biosynthesis and colorectal tumorigenesis by deubiquitinating FTO.

Yaya Qiao, Chenxi Wang, Huanle Liu, Huanran Sun, Huifang Zhao, Qijun Zhang, Xintong Dai, Mingming Sun, Taoyuan Wang, Tao He and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yaya Qiao *State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Chenxi Wang *State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Huanle Liu *State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Huanran Sun *State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Huifang ZhaoSchool of Integrative Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Qijun ZhangState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Xintong DaiState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Mingming SunState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Taoyuan WangCardiothoracic Surgery Department, Characteristic Medical Center of the Chinese People's Armed Police Force, Tianjin, China.
Tao HeDepartment of Pathology, Characteristic Medical Center of The Chinese People's Armed Police Force, Tianjin, China.
Zhen LiGuangzhou key laboratory for clinical rapid diagnosis and early warning of infectious diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China.
Yanping LiDepartment of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, China.
Jun XueTumor Research Institute, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Chunze ZhangTumor Research Institute, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China. chunze.zhang@nankai.edu.cn.ORCID 0000-0002-2063-5631
Changliang ShanState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China. changliangshan@nankai.edu.cn.ORCID 0000-0002-4906-1686
Shuai ZhangSchool of Integrative Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, China. shuaizhang@tjutcm.edu.cn.ORCID 0000-0003-0272-0856

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous studies demonstrated that the fat mass and obesity-associated protein (FTO) is upregulated in colorectal cancer (CRC). It demethylates G6PD/PARP1 and SLC7A11/GPX4 mRNAs, thereby protecting CRC from DNA damage and ferroptotic cell death. However, the mechanisms underlying FTO upregulation in CRC remain unclear. Unexpectedly, we show Ubiquitin-specific peptidase 30 (USP30) binds serine/glycine and senses their levels to protect FTO from proteosome degradation. Stabilized FTO demethylates 3-phosphoglycerate dehydrogenase (PHGDH) and phosphoserine aminotransferase 1 (PSAT1) mRNAs and inhibits their degradation in an m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOCarcinogenesisColorectal NeoplasmsGlycineSerineAnimalsCell Line, TumorHumansMiceMice, NudePhosphoglycerate DehydrogenaseTransaminasesUbiquitinationAlpha-Ketoglutarate-Dependent Dioxygenase FTOGlycinePhosphoglycerate Dehydrogenasephosphoserine aminotransferaseSerineTransaminases

Identifiers

PMID41652187
PMCPMC13433793

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.