Evidence map›Paper›PMID 41652156›Full record

ArticleGeroScience2026

PTUPB improves cognitive function in Alzheimer's disease associated with enhancing cerebral vascular myogenic response and attenuating vascular remodeling.

Gilbert C Morgan, Andrew Gregory, Chengyun Tang, Sung Hee Hwang, Jane J Border, Jing Xu, Yedan Liu, Shan Bai, Tae Jin Lee, Cameron Cantwell and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Gilbert C MorganDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Andrew GregoryDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Chengyun TangDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Sung Hee HwangEntomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, USA.
Jane J BorderPharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Jing XuDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Yedan LiuPharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Shan BaiCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Tae Jin LeeCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Cameron CantwellDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
David BunnDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Karen M WagnerEntomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, USA.
Christophe MorisseauEntomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, USA.
Carly PittmanDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Alina NgoDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Peter OsayiDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Aditi PabbidiDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Philip O'HerronDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Zsolt BagiDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Jessica A FilosaDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA.
Hongwei YuAnesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Cindy McReynoldsEicOsis L.L.C, Davis, CA, USA.
Bruce D HammockEntomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, USA.
Richard J RomanPharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Fan FanDepartment of Physiology, Medical College of Georgia, Augusta University, 1462 Laney Walker Blvd, Augusta, GA, 30912, USA. ffan@augusta.edu.ORCID http://orcid.org/0000-0003-1463-3610

Funding

Vascular mechanisms of inhibition of sEH as a novel therapy for AD/ADRDRF1AG079336 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI FAN, FAN, ROMAN, RICHARD J. · 2022 to 2022
$1.7M
Vascular mechanisms of inhibition of sEH as a novel therapy for AD/ADRDR01AG079336 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI Fan Fan, Richard J. Roman · 2025 to 2026
$1.1M
American Heart Association 25PRE1365157Harrington Brain Health Medicine Scholar Award A25-1690National Institute Health AG057842National Institute of Health AG057842National Institute of Health AG079336National Institute of Health NS126920National Institute of Health P20GM104357National Institute of Health P42ES004699National Institute of Health R35ES030443National Institute of Health U54NS127758NIA NIH HHS R01 AG079336NIA NIH HHS RF1 AG079336Physiology Faculty Startup Fund from Augusta University TRIBA
6 · The paper itself

Abstract

Genetic studies have linked EPHX2 (encoding soluble epoxide hydrolase, sEH) and PTGS2 (encoding cyclooxygenase-2, COX-2) to Alzheimer's disease (AD). Elevated levels of sEH and COX-2 found in AD patients and animals suggest their involvement in neurodegeneration, glial activation, vascular dysfunction, and inflammation. This study evaluated the effects of a new dual sEH/COX-2 inhibitor, PTUPB, on cerebrovascular function and cognition in TgF344-AD rats. The rats received oral PTUPB (2 mg/kg/day) for 25 days. Body weight, plasma glucose, and HbA1c levels remained stable between PTUPB- and vehicle-treated AD rats. PTUPB significantly improved recognition memory in AD rats, as detected by the novel object recognition test. Pressure myography showed that PTUPB restored myogenic responses and increased the distensibility of the middle cerebral arteries (MCAs) in AD rats. Acute PTUPB (0.1 and 1 μM) enhanced myogenic contraction in response to elevated perfusion pressure in AD MCAs, with minimal effects in wild-type vessels. Transcriptomic analysis of cerebral vascular smooth muscle cells from AD rats revealed that PTUPB influences genes involved in contractility, extracellular matrix remodeling, inflammation, and oxidative stress. These results provide new evidence that dual inhibition of sEH and COX-2 improves cognition in AD and is associated with enhanced myogenic response via attenuation of vascular remodeling. Our findings highlight the potential of PTUPB as a therapeutic approach for cerebrovascular dysfunction in AD.

Indexed as

Alzheimer’s diseaseCyclooxygenase-2Myogenic responseSoluble epoxide hydrolaseVascular remodeling

Identifiers

PMID41652156

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.