Evidence map›Paper›PMID 41652144›Full record

ReviewClinical rheumatology2026

Overlapping autoimmunity and demyelination syndromes associated with TNF inhibitor therapy.

Rula Daood, Mohammad E Naffaa, Olga Azrilin, Fadi Hassan, Helana Jeries, Putterman Chaim

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rula DaoodRheumatology Unit, Galilee Medical Center, Nahariya, Israel. rula.daood@gmail.com.ORCID http://orcid.org/0009-0000-9333-455X
Mohammad E NaffaaRheumatology Unit, Galilee Medical Center, Nahariya, Israel.
Olga AzrilinAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Fadi HassanRheumatology Unit, Galilee Medical Center, Nahariya, Israel.
Helana JeriesRheumatology Unit, Galilee Medical Center, Nahariya, Israel.
Putterman ChaimRheumatology Unit, Galilee Medical Center, Nahariya, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disorder of the central nervous system. We describe a case of a 31-year-old male with ankylosing spondylitis who developed optic neuritis and transverse myelitis accompanied by positive anti-MOG antibodies, and subsequently features consistent with systemic lupus erythematosus (SLE), beginning 3 months after initiating adalimumab. Adalimumab was discontinued, and the patient was treated with pulsed intravenous methylprednisolone followed by rituximab with significant improvement in clinical, imaging, and laboratory manifestations of the disease. This case highlights a rare constellation of overlapping autoimmune diseases, with both MOGAD and SLE emerging after anti-TNF antibody exposure in a patient with ankylosing spondylitis.

Indexed as

AdalimumabAutoimmunityDemyelinating DiseasesLupus Erythematosus, SystemicMyelin Oligodendrocyte Glycoprotein Antibody-Associated DiseaseSpondylitis, AnkylosingTumor Necrosis Factor InhibitorsAdultHumansMaleMethylprednisoloneMyelin-Oligodendrocyte GlycoproteinMyelitis, TransverseOptic NeuritisRituximabTumor Necrosis Factor-alphaAdalimumabMethylprednisoloneMyelin-Oligodendrocyte GlycoproteinRituximabTumor Necrosis Factor-alphaTumor Necrosis Factor InhibitorsAnkylosing spondylitisMyelin oligodendrocyte glycoprotein antibody-associated diseaseSystemic lupus erythematosus

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.