Trial reportScientific reports2026
The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The effects of high-intensity interval training on glucose metabolism, inflammatory responses, and functional recovery in patients with diabetic peripheral neuropathy.Frontiers in endocrinology · 2026Trial
- Novel therapeutic strategies targeting mitochondrial quality control for metabolic dysfunction-associated steatotic liver disease.Frontiers in physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Interoception, the process by which the nervous system perceives and interprets internal bodily signals, is essential for athletes to effectively modulate motor decisions but may be impaired after exhaustive exercise. This study investigated the effects of pyrroloquinoline quinone (PQQ), nicotinamide mononucleotide (NMN), and their combination on interoception following acute exhaustive exercise. Sixty participants were randomly assigned in a double-blind, placebo-controlled trial to receive either placebo (320 mg cornflour), PQQ (20 mg PQQ + 300 mg cornflour), NMN (300 mg NMN + 20 mg cornflour), or a combined supplement (20 mg PQQ + 300 mg NMN). Supplements were ingested 60 min before completing an acute exhaustive exercise protocol using the Bruce treadmill test. Interoception was measured using the Body Perception Questionnaire (BPQ) and the Multidimensional Assessment of Interoceptive Awareness (MAIA) at baseline and post-exercise. Group differences were examined using chi-square and one-way ANOVA, while mixed-design ANOVA was applied to evaluate interoception and exercise capacity indicators. Significant improvements over time were observed in BPQ scores (89.45 vs. 95.08, p = 0.006), Self-regulation (2.79 vs. 3.02, p = 0.015), Body Listening (2.36 vs. 2.76, p < 0.001), and Trusting (2.97 vs. 3.21, p = 0.031). Body listening was the only domain that demonstrated a significant group × time interaction (p = 0.016), with the PQQ group showing significant improvement (p < 0.001). These findings suggest that PQQ supplementation may enhance specific aspects of interoception following acute exhaustive exercise.
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Registered trials
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