Evidence map›Paper›PMID 41651853›Full record

ArticleNature communications2026

Zebrafish macrophages convert physical wound signals into rapid vascular permeabilization.

Zaza Gelashvili, Zhouyang Shen, Yanan Ma, Mark Jelcic, Philipp Niethammer

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Zaza GelashviliCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2420-3916
Zhouyang ShenCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6524-8993
Yanan MaCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6711-1659
Mark JelcicCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Philipp NiethammerCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. niethamp@mskcc.org.ORCID http://orcid.org/0000-0003-4175-4012

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Chemical and Physical Mechanisms of Wound DetectionR35GM140883 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Philipp Michael Niethammer · 2021 to 2026
$3.8M
National Cancer Center P30CA008748NCI NIH HHS P30 CA008748NIGMS NIH HHS R35 GM140883U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM140883
6 · The paper itself

Abstract

Blood vessels near injury sites rapidly dilate, become permeable, and release serum and leukocytes into the wounded tissue to support healing and regeneration. How the vasculature senses distant homeostatic tissue perturbations within seconds-to-minutes remains incompletely understood. Using high-speed imaging of live zebrafish larvae, we monitor two hallmark vascular responses to injury: vessel dilation and serum exudation. By genetic, pharmacologic, and osmotic perturbation along with leukocyte depletion, we show that the cPla

Indexed as

Blood VesselsCapillary PermeabilityMacrophagesMechanotransduction, CellularWound HealingZebrafishAnimalsArachidonate 5-LipoxygenaseEpoxide HydrolasesLarvaZebrafish ProteinsArachidonate 5-LipoxygenaseEpoxide Hydrolasesleukotriene A4 hydrolaseZebrafish Proteins

Identifiers

PMID41651853
PMCPMC12916771

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.