Evidence map›Paper›PMID 41651838›Full record

ArticleNature communications2026

Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety.

Thomas Larrieu, Fabio Grieco, Charline Carron, Marta Vilademunt, Crystal Weber, Kyllian Ginggen, Aurélie Delacrétaz, Hector Gallart-Ayala, Mumeko C Tsuda, Heather A Cameron and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Thomas LarrieuCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland. thomas.larrieu@chuv.ch.ORCID 0000-0003-2406-356X
Fabio GriecoCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
Charline CarronCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
Marta VilademuntCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
Crystal WeberCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
Kyllian GinggenCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
Aurélie DelacrétazCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
Hector Gallart-AyalaMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-2333-0646
Mumeko C TsudaSection on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Heather A CameronSection on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3245-5777
Chin B EapCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
Julijana IvanisevicMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-8267-2705
Pierre MagistrettiCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
Evgenia SaltaLaboratory of Neurogenesis and Neurodegeneration, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Giorgia TosoniLaboratory of Neurogenesis and Neurodegeneration, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.ORCID 0000-0003-0787-8556
Dilara AyyildizLaboratory of Neurogenesis and Neurodegeneration, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Ludovic TelleyUniversity Claude Bernard Lyon 1, MeLiS-UCBL-CNRS UMR 5284-INSERM, Lyon, France.ORCID 0000-0002-5041-1997
Alexandre DayerDepartment of Psychiatry, Faculty of Medicine, University of Geneva; Department of Mental Health and Psychiatry, Geneva University Hospital, Geneva, Switzerland.
Camille PiguetDepartment of Psychiatry, Faculty of Medicine, University of Geneva; Department of Mental Health and Psychiatry, Geneva University Hospital, Geneva, Switzerland.
Nicolas ToniCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland. nicolas.toni@unil.ch.ORCID 0000-0001-5585-268X

Funding

ERCSwiss National Science Foundation | National Center of Competence in Research Affective Sciences - Emotions in Individual Behaviour and Social Processes (National Centre of Competence in Research Affective Sciences) 31003A_173128
6 · The paper itself

Abstract

Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA16:0 levels are sufficient to reduce the in vitro proliferation of adult hippocampal neural stem/progenitor cells. In humans, the main LPA receptor LPA

Indexed as

AnxietyBlood PlateletsHippocampusLysophospholipidsNeurogenesisStress, PsychologicalAnimalsCell ProliferationDentate GyrusFemaleHumansMaleMiceMice, Inbred C57BLNeural Stem CellsPolymorphism, Single NucleotideLysophospholipidsReceptors, Lysophosphatidic Acid

Identifiers

PMID41651838
PMCPMC12987988

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.