ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
In Vivo Screen of Parkinson's Disease GWAS Risk Genes Identifies
Maria Armakola, Anika P Wilen, Bernabe I Bustos, Pingping Song, Yi-Zhi Wang, Adeyemi K Thomas, Nandkishore R Belur, Joseph R Mazzulli, Jeffrey N Savas, Robert G Kalb and 1 more
Abstract read
In one paragraphArticle in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Maria ArmakolaThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 maria.armakola@northwestern.edu.
Anika P WilenThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.ORCID 0000-0002-8310-9946 Bernabe I BustosThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Pingping SongThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Yi-Zhi WangThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.ORCID 0000-0001-5279-5034 Adeyemi K ThomasThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.ORCID 0009-0008-4681-345X Nandkishore R BelurThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Joseph R MazzulliThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Jeffrey N SavasThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.ORCID 0000-0002-8173-5580 Robert G KalbThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Dimitri KraincThe Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Funding
Mechanistic Analysis of Genetic Modifiers in Parkinson's DiseaseR35NS122257 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DIMITRI KRAINC · 2021 to 2026
$6.8MThe role of a-synuclein accumulation in lysosomal hydrolase trafficking and functionR01NS092823 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Joseph R Mazzulli · 2015 to 2026
$4.8MMechanisms of gene regulation and RNA processing in synucleinopathiesR01NS118824 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAZZULLI, JOSEPH R · 2020 to 2024
$2.8MOrbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration HubS10OD032464 · OD · NORTHWESTERN UNIVERSITY · PI SAVAS, JEFFREY NICHOLAS · 2023 to 2023
$1.3MNIH HHS S10 OD032464NINDS NIH HHS R01 NS092823NINDS NIH HHS R01 NS118824NINDS NIH HHS R35 NS122257
6 · The paper itselfAbstract
Parkinson's disease (PD) is a late-onset neurodegenerative disease characterized by preferential degeneration of midbrain dopaminergic neurons and α-synuclein-containing Lewy bodies that are found in both familial and sporadic forms. Genome-wide association studies (GWAS) have identified many loci associated with risk of sporadic PD, but their role in PD pathogenesis remains largely unknown. We screened a subset of GWAS genes in
Indexed as
alpha-SynucleinCaenorhabditis elegans ProteinsDopaminergic NeuronsParkinson DiseaseUbiquitin-Protein LigasesAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCarrier ProteinsGenome-Wide Association StudyHumansNerve DegenerationNerve Tissue ProteinsSerine Proteasesalpha-SynucleinCaenorhabditis elegans ProteinsCarrier ProteinsNerve Tissue ProteinsSerine ProteasesSNCAIP protein, humanTPPP protein, humanUbiquitin-Protein LigasesC. elegansGWAShuman dopaminergic neuronsiPSCParkinson's diseaseα-synuclein
Identifiers
PMID41651665
PMCPMC12981288
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