Evidence map›Paper›PMID 41651600›Full record

ReviewClinics in chest medicine2026

Pediatric Sepsis: Evolving Subphenotypes, Overlap Syndromes, and the Path to Precision Therapies.

Steven D Ham, Julie C Fitzgerald, Robert B Lindell

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinics in chest medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Steven D HamDivision of Critical Care Medicine, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Pediatric Sepsis Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Julie C FitzgeraldDivision of Critical Care Medicine, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Pediatric Sepsis Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Robert B LindellDivision of Critical Care Medicine, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Pediatric Sepsis Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: LindellR@chop.edu.

Funding

Targeting Immune Dysregulated Endotypes in Sepsis (TIDES)K23GM159013 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert B Lindell · 2025 to 2026
$359k
NIGMS NIH HHS K23 GM159013
6 · The paper itself

Abstract

Pediatric sepsis is a complex syndrome shaped by developmental considerations, age-specific physiology, immunologic heterogeneity, and hyperinflammatory overlap syndromes. Recent evidence underscores a dynamic interplay between hyperinflammation and immunoparalysis in pediatric patients with sepsis, emphasizing the need for rapid, personalized diagnostic tools. While revised pediatric scoring systems and targeted immunotherapies have been developed, significant knowledge gaps remain regarding optimal timing and patient selection for immunomodulatory interventions. This article consolidates current understanding of pediatric sepsis pathobiology, explores emerging pediatric subphenotypes, and examines early stage clinical trials investigating precision medicine approaches in pediatric sepsis.

Indexed as

Precision MedicineSepsisChildHumansImmunotherapyPhenotypeImmune dysregulationImmunomodulationOutcomesPediatric sepsis

Identifiers

PMID41651600
PMCPMC13147271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.