Neuroimmune Mechanisms Transforming Acute Injury to Long-Term Brain Dysfunction After Sepsis.

Kate A Giffin, Benjamin H Singer

Abstract readReview

In one paragraph

Review in Clinics in chest medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Early amyloid pathology in mice synergistically worsens post-sepsis behavioral impairment and microglial synaptic phagocytosis.Brain, behavior, & immunity - health · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kate A GiffinNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.

Benjamin H SingerDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Weil Institute for Critical Care Research and Innovation, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: singerb@med.umich.edu.

Funding

Enhancement of Brain Dysfunction in Sepsis Survivors by Alzheimer’s Disease NeuropathologyR01AG074968 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Benjamin Herschel Singer · 2022 to 2026

$3.3M

NIA NIH HHS R01 AG074968

6 · The paper itself

Abstract

Sepsis is frequently accompanied by acute brain dysfunction. Sepsis survivors commonly experience multifaceted symptoms of brain injury, including cognitive and mental health disorders. Systemic and neuroinflammatory changes during and after sepsis have been reported in clinical and preclinical studies, including glial activation, metabolic and oxidative stress, vascular injury and barrier dysfunction, and brain invasion of circulating inflammatory cells and signals. These processes may lead to dysfunction through a common pathway of synapse loss and brain circuit disruption. Further investigation is needed both to understand the relationship between acute brain injury in sepsis and long-term brain dysfunction and to develop treatments for survivors.

Indexed as

NeuroimmunomodulationSepsisSepsis-Associated EncephalopathyAnimalsHumansDeliriumMicrogliaPost-intensive care syndromeSepsisSepsis-associated encephalopathySynaptic pruning

Identifiers

PMID41651594

DOI10.1016/j.ccm.2025.11.002

PMCPMC13482970

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.