Evidence map›Paper›PMID 41651415›Full record

ArticleThe Journal of biological chemistry2026

GPR39-mediated molecular signaling by bile acids.

Yanyun Huang, Zhentao Zi, Chenliang Xia, Yi Rao

Erratum issuedAbstract read
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In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yanyun HuangDepartment of Pharmacology School of Basic Medical Sciences and Center for AI Therapeutics, Fudan University Shanghai Medical College, Shanghai, China; School of Basic Medical Sciences, Chinese Institutes for Medical Research (CIMR), Capital Medical University, Beijing, China.
Zhentao ZiLaboratory of Neurochemical Biology, Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua-NIBS (PTN) Graduate Program, School of Life Sciences, Beijing, China; Department of Chemical Biology, College of Chemistry and Chemical Engineering; School of Pharmaceutical Sciences, Peking University, Beijing, China.
Chenliang XiaLaboratory of Neurochemical Biology, Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua-NIBS (PTN) Graduate Program, School of Life Sciences, Beijing, China; Department of Chemical Biology, College of Chemistry and Chemical Engineering; School of Pharmaceutical Sciences, Peking University, Beijing, China.
Yi RaoDepartment of Pharmacology School of Basic Medical Sciences and Center for AI Therapeutics, Fudan University Shanghai Medical College, Shanghai, China; School of Basic Medical Sciences, Chinese Institutes for Medical Research (CIMR), Capital Medical University, Beijing, China; Laboratory of Neurochemical Biology, Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua-NIBS (PTN) Graduate Program, School of Life Sciences, Beijing, China; Department of Chemical Biology, College of Chemistry and Chemical Engineering; School of Pharmaceutical Sciences, Peking University, Beijing, China. Electronic address: yrao@pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bile acids (BAs), long known for roles in food emulsion, also function as biological signals. By measuring intracellular calcium, we have recently discovered that GPR39, a G protein-coupled receptor, is a receptor for 3-O-sulfated BAs including lithocholic acid 3-sulfate (LCAS), taurolithocholic acid 3-sulfate (TLCAS) and glycolithocholic acid 3-sulfate (GLCAS) in cultured cells and in pancreatic acinar cells. We have now used multiple assays from electrophysiologic recording in Xenopus oocytes, Ca

Indexed as

Bile Acids and SaltsReceptors, G-Protein-CoupledSignal TransductionAnimalsHumansMiceMice, KnockoutBile Acids and SaltsGPR39 protein, humanReceptors, G-Protein-Coupledbile acidsExtracellular signal-regulated Kinase (ERK)GPR39G protein-coupled receptorsignal transduction

Identifiers

PMID41651415
PMCPMC12961325

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.