ArticleActa biomaterialia2026
Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo.
Article in Acta biomaterialia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The development of biomaterials that mimic native bone remains a major challenge in regenerative medicine. Here, we present a bioinspired platform using high-density collagen hydrogels with tunable mineral content. These engineered microenvironments promote rapid osteogenesis in vitro without osteogenic supplements and accelerate bone regeneration in vivo in critical-sized defects. By modulating mineralization, we demonstrate that early mechanosensitive signaling in human mesenchymal stem cells is linked to matrix stiffness and biochemical composition. Within two hours, focal adhesion formation decreased with increasing mineral content, and fully mineralized scaffolds significantly increased nuclear YAP1 localization. By 24 h, RUNX2 expression was markedly increased in fully mineralized scaffolds, with 40.7 ± 3.9% RUNX2
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