Trial reportThe Journal of nutrition2026
Maternal Adiposity and DNA Methylation of TfR2 and HJV Genes in Early Pregnancy: Mediating Role of Inflammation and Consequences for Iron Status.
Trial report in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Iron and Other Metal Ions in Human Health and Disease.MedComm · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowing evidence shows that obesity influences iron status during pregnancy; however, it is unknown whether maternal obesity is associated with epigenetic changes in transferrin receptor 2 (TfR2) and hemojuvelin (HJV).
objectivesThis study aimed to explore the association between adiposity and DNA methylation in TfR2 and HJV in early pregnancy and the mediating effect of inflammation on this association.
methodsThis cross-sectional study used data from a double-blind randomized controlled trial in singleton pregnant women with normal weight (BMI: 18.5-24.9 kg/m
resultsA total of 65 pregnant women were included, 34 with normal weight, and 31 with obesity. Compared to women of normal-weight, those with obesity showed: lower percentage DNA methylationat TfR2z1 cytosine-phosphate-guanine (CpG) sites 5, 6, 8-10 and the mean TfR2z1 methylation (mean TfR2z1 methylation 5.80% vs 6.92%, P = 0.004); lower percentage of DNA methylation at TfR2z2 CpG sites 5 and 6 (12.5% vs 14.7%, P = 0.035; 17.8% vs 20.1%, P = 0.031); higher percentage DNA methylation at HJVz1 CpG site 3 (HJVz1 CpG 3 45.3% vs 43.4%, P = 0.010) and HJVz2 CpG site 2 and the mean HJVz2 methylation (HJVz2 CpG 2 43.2% vs 37.9%, P < 0.001, mean HJVz2 methylation 65.9% vs 61.6%, P < 0.001). Adjusting for covariates, DNA methylation at TfR2z1 was negatively and HJVz2 positively associated with all adiposity measures (TfR2z1, BMI β = -0.288, P = 0.030; HJVz2 β = 0.459, P < 0.001). Inflammation showed a mediating effect on the association between all adiposity measures and DNA methylation at HJVz1 (P = 0.019).
conclusionsMaternal adiposity is associated with epigenetic alterations in the iron metabolism genes TfR2 and HJV in early pregnancy, with modifications in HJV appearing to be mediated by inflammatory pathways.
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