ReviewCell genomics2026
Universal paralogs provide a window into evolution before the last universal common ancestor.
Review in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The study of early evolutionary history provides an account of how the foundational features of life as we know it first emerged. Phylogenetic analysis is a powerful method in the study of early evolution because it uses molecular evidence that has been inherited from the ancient organisms themselves. Here, we describe an important yet understudied type of protein family, universal paralogs, that retain phylogenetic signals from evolutionary events predating the last universal common ancestor of life, offering a unique window into early evolution. We survey recent advances in the study of universal paralogs and discuss how emerging computational tools enhance our ability to use these protein families to describe the very earliest stages of evolution with increasing detail and accuracy. Such research will greatly improve our understanding of how life emerged and subsequently evolved on the ancient Earth.
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