Evidence map›Paper›PMID 41650973›Full record

ArticleCancer cell2026

Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma.

Nourhan Abdelfattah, Sivaraman Natarajan, Han Nhat Tran, Thomas Wong, Maryam Faisal, Jose Maldonado, Rachael McMinimy, Hannah Borland, Shu-Hsia Chen, Hong Zhao and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nourhan AbdelfattahDepartment of Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA.
Sivaraman NatarajanThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME 04609, USA.
Han Nhat TranDepartment of Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA.
Thomas WongDepartment of Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA; Texas A&M Health Science Center School of Medicine, Bryan, TX 77807, USA.
Maryam FaisalDepartment of Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA.
Jose MaldonadoDepartment of Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA.
Rachael McMinimyThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME 04609, USA.
Hannah BorlandDepartment of Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA.
Shu-Hsia ChenCenter for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA.
Hong ZhaoDepartment of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Houston, TX 77030, USA; Advanced Cellular and Tissue Microscopy, Houston Methodist Research Institute, Houston, TX 77035, USA.
Matthew VasquezAdvanced Cellular and Tissue Microscopy, Houston Methodist Research Institute, Houston, TX 77035, USA.
Freddys F RodriguezDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Carston R WagnerDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Fernando CamargoDepartment of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA 02138, USA.
James OlsonBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98105, USA.
Joshy GeorgeJackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Kyuson YunDepartment of Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Neurology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: kyun@houstonmethodist.org.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
Targeting Effector Immune cells to Cancer with Chemically Self-Assembled Nanorings (CSANs)R01CA247681 · NCI · UNIVERSITY OF MINNESOTA · PI WAGNER, CARSTON R. · 2020 to 2024
$2.8M
S100A4 mediated immune suppression in GBMR01NS121405 · NINDS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI YUN, KYUSON · 2021 to 2025
$2.2M
Carbon-11 Labeled Sarcosine: Mechanism of Action and Initial Performance in Prostate CancerR21CA191052 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PIERT, MORAND RUEDIGER, RAJENDIRAN, THEKKELNAYCKE · 2015 to 2016
$322k
NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA247681NCI NIH HHS R21 CA191052NINDS NIH HHS R01 NS121405
6 · The paper itself

Abstract

Molecular mechanisms underlying sex-specific differences in cancer incidence and therapy responses are under intense investigation. Here, we report sex-biased functions of Yap1 in multiple cancer types in human and mouse. Through integrated multi-omics analyses, we demonstrate that Yap1 deletion significantly extends survival in male but not female Sonic Hedgehog (SHH) medulloblastomas (MB) models. While Yap1 is required to maintain stem-like cells in both sexes, Yap1 plays a more critical role in immune evasion in males. Mechanistically, YAP1 is essential for activating Cd276/B7-H3 expression to mediate CD8

Indexed as

Adaptor Proteins, Signal TransducingB7 AntigensCerebellar NeoplasmsMedulloblastomaTranscription FactorsTumor EscapeAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansMaleMiceSex FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingB7 AntigensCD276 protein, humanTranscription FactorsYAP1 protein, humanYap1 protein, mouseYAP-Signaling Proteinsbrain tumorcancer stem cellsCD276/ B7-H3immune evasionimmunotherapymedulloblastomasex biastumor microenvironmentYAP1

Identifiers

PMID41650973
PMCPMC12885226

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.