ArticleCancer cell2026
CCL3 is produced by aged neutrophils across cancers and promotes tumor growth.
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Article in Cancer cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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Who cites it
4 citing papers in PubMed.
- Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Serial Thermal Ablation Induces Abscopal Antitumor Immunity and Reveals Targetable CSF1R-Dependent Resistance in Pancreatic Cancer.bioRxiv : the preprint server for biology · 2026Article
- MORPHE: Bridging Image Generation and Spatial Omics for Tissue Synthesis.bioRxiv : the preprint server for biology · 2026Article
- Single-cell analysis identifies a VIM+ glioma stem-like vascular-immune state linked to myeloid OSM signaling and CEBPD activity.Frontiers in immunology · 2026Article
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Authors and funding
31 authors.
Evangelia BolliDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Pratyaksha WirapatiDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Mehdi HichamDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Yuxuan XieDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Marie SiwickiSnyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Florent DuvalDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Anne-Gaëlle GoubetDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Máté KissDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Béatrice ZittiDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Thomas ZwahlenDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland; Translational Data Science Group, Swiss Institute of Bioinformatics, Lausanne, Switzerland; Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Sheri McdowellDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Ruben BillDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Simona AngeraniDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Camilla EngblomSciLifeLab, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Seth AndersonBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Aiping JiangBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Oliver HartleyDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
David B SykesMass General Brigham Cancer Center, Boston, MA, USA.
Maja JankovicLady Davis Institute for Medical Research, McGill University, Montréal, Quebec, Canada.
Nadine FournierTranslational Data Science Group, Swiss Institute of Bioinformatics, Lausanne, Switzerland; Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Matthias GunzerInstitute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Leibniz-Institut für Analytische Wissenschaften ISAS -e.V., Dortmund, Germany.
David TarussioDepartment of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Stéphanie TissotDepartment of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Peter M SadowCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Surgery, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
William C FaquinCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Surgery, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
Moshe Sade-FeldmanBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Ralph WeisslederMass General Brigham Cancer Center, Boston, MA, USA; Center for Systems Biology, Massachusetts General Hospital, Cambridge St, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Fruit St, Boston, MA, USA; Department of Systems Biology, Harvard Medical School, Longwood Ave, Boston, MA, USA.
Sara PaiDepartment of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
François MercierLady Davis Institute for Medical Research, McGill University, Montréal, Quebec, Canada.
Robert MangusoBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mikaël J PittetDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; AGORA Cancer Research Center, and Swiss Cancer Center Leman, Lausanne, Switzerland; Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland; Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne, Switzerland; Department of Oncology, Geneva University Hospitals (HUG), Geneva, Switzerland. Electronic address: mikael.pittet@unige.ch.
Funding
Strategies to Overcome Immune Resistance in Head and Neck CancersP01CA240239 · NCI · YALE UNIVERSITY · PI SARTOR, MAUREEN AGNES · 2019 to 2023
$8.4MEarly detection and risk of head and neck cancer through immune based spatial omicsU01DE033324 · NIDCR · YALE UNIVERSITY · PI Sara Isabel Pai · 2023 to 2026
$2.7MCue-101 and TCR-T cell Combinatorial Strategy for HPV+ Head and Neck CancersR01CA278212 · NCI · YALE UNIVERSITY · PI Sara Isabel Pai · 2024 to 2026
$2.0MBioorthogonal probe development for highly parallel in vivo imagingR33CA277820 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2023 to 2025
$1.2MNCI NIH HHS P01 CA240239NCI NIH HHS R01 CA278212NCI NIH HHS R33 CA277820NIDCR NIH HHS U01 DE033324
Abstract
Tumor-associated neutrophils (TANs) are abundant across cancers, yet their phenotypic diversity and functional states remain poorly defined. Here, we introduce a cell-type probability classifier that recovers low-transcript neutrophils from scRNAseq datasets, enabling pan-cancer analyses of TAN heterogeneity. Across >190 human and murine tumors, we identify a conserved differentiation trajectory that culminates in a terminal CCL3
Indexed as
Chemokine CCL3NeoplasmsNeutrophilsAnimalsCell DifferentiationCellular SenescenceGene Expression Regulation, NeoplasticHumansMiceReceptors, CCR1Signal TransductionTumor MicroenvironmentCcl3 protein, mouseCCR1 protein, humanChemokine CCL3Receptors, CCR1CCL3-CCR1 signalingCRISPR perturbationhypoxianeutrophil agingneutrophil differentiationneutrophil heterogeneitypan-cancer analysissingle-cell RNA sequencingtumor microenvironmenttumor-promoting neutrophils
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.