Evidence map›Paper›PMID 41650958›Full record

ArticleStem cell reports2026

Comparison with Ezh2 reveals the PRC2-dependent functions of Jarid2 in hematopoietic stem Cell lineage commitment.

Hassan Bjeije, Wentao Han, Shuyang Lin, Nancy Issa, Aishwarya Krishnan, Infencia Xavier Raj, Jason Arand, Yanan Li, Wei Yang, Jeffrey A Magee and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Hassan BjeijeDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wentao HanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shuyang LinDivision of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Nancy IssaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Aishwarya KrishnanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Infencia Xavier RajDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jason ArandDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yanan LiDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wei YangDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jeffrey A MageeDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Grant A ChallenDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: grantchallen@wustl.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies showed the polycomb repressive complex 2 (PRC2) co-factor Jarid2 represses self-renewal transcriptional networks in mouse multipotent progenitor cells (MPPs). But only a fraction of de-repressed HSC-specific genes were associated with loss of H3K27me3, implying Jarid2 may have non-canonical (PRC2-independent) functions in hematopoiesis. We sought to delineate these potential PRC2-independent functions by comparing stem and progenitor cells genetically deficient for either Jarid2 or Ezh2 (enzymatic component of PRC2). Loss of Ezh2 increased myeloid differentiation but with a defect in lymphopoiesis. In contrast, loss of Jarid2 enhanced multi-lineage differentiation proportionally. Single-cell transcriptomics showed loss of Jarid2 had minimal impact across progenitor populations, but loss of Ezh2 led to accumulation of lymphoid-biased MPP4 cells and B cell progenitors in the bone marrow. Functional assays confirmed a differentiation block at the pre-pro-B cell stage. These data suggest the major PRC2-dependent function of Jarid2 in hematopoietic progenitors is restriction of myeloid differentiation potential.

Indexed as

Cell LineageEnhancer of Zeste Homolog 2 ProteinHematopoietic Stem CellsPolycomb Repressive Complex 2AnimalsCell DifferentiationHematopoiesisLymphopoiesisMiceEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseJarid2 protein, mousePolycomb Repressive Complex 2

Identifiers

PMID41650958
PMCPMC12985378

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.