Article in Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
31 authors.
Hemmo A F YskaINSERM U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau, ICM, France.ORCID 0009-0002-7973-2724
Marianne GolseDepartment of Neuroradiology, AP-HP, Pitié-Salpêtrière University Hospital, Paris, France.
Damien GalanaudDepartment of Neuroradiology, AP-HP, Pitié-Salpêtrière University Hospital, Paris, France.
Hernan M AmartinoHospital Universitario Austral, Buenos Aires, Argentina.
Caroline BergnerUniversity of Leipzig Medical Center, Department of Neurology, Myelin Research Center Leipzig, Germany.ORCID 0000-0002-0327-1389
Fabio BruschiCOALA (Center for Diagnosis and Treatment of Leukodystrophies), Unit of Pediatric Neurology, "Vittore Buzzi" Children's Hospital, Milan, Italy.
Florian S EichlerMassachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0001-6836-1089
Ali FatemiThe Moser Center for Leukodystrophies, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-4116-6990
Àngeles García-CazorlaNeurometabolic Unit, Neurology Department, Institut de Recerca Sant Joan de Déu, CIBERER and MetabERN, Hospital Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0001-9853-688X
Marta Gomez-ChiariDiagnostic Imaging Department, Sant Joan de Déu Barcelona Children's Hospital, Esplugues de Llobregat, Spain.
Wolfgang KöhlerUniversity of Leipzig Medical Center, Department of Neurology, Myelin Research Center Leipzig, Germany.ORCID 0000-0002-6058-9545
Troy LundDivision of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis.ORCID 0000-0001-9174-8919
Eric J MallackThe Moser Center for Leukodystrophies, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-2678-8807
Marco MoscatelliNeuroradiology Unit, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.ORCID 0000-0002-6745-474X
Patricia L MusolinoCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0001-8724-5649
Jennifer L Orthmann-MurphyDepartment of Neurology, University of Pennsylvania, Philadelphia.ORCID 0000-0002-2909-1722
Cecilia ParazziniCOALA (Center for Diagnosis and Treatment of Leukodystrophies), Unit of Pediatric Neurology, "Vittore Buzzi" Children's Hospital, Milan, Italy.
Petra J W PouwelsDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, the Netherlands.ORCID 0000-0001-8430-0606
Juliana Ribeiro-ConstanteNeurometabolic Unit, Neurology Department, Institut de Recerca Sant Joan de Déu, CIBERER and MetabERN, Hospital Sant Joan de Déu, Barcelona, Spain.
Stefan D RoosendaalDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, the Netherlands.ORCID 0000-0002-3763-4774
Ettore SalsanoUnit of Rare Neurological Diseases, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.ORCID 0000-0001-9167-1878
Caroline SevinINSERM U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau, ICM, France.ORCID 0000-0002-5856-068X
Amena Smith FineThe Moser Center for Leukodystrophies, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Davide TondutiCOALA (Center for Diagnosis and Treatment of Leukodystrophies), Unit of Pediatric Neurology, "Vittore Buzzi" Children's Hospital, Milan, Italy.ORCID 0000-0001-9371-7454
Keith Van HarenDepartment of Neurology & Department of Pediatrics, Stanford University School of Medicine, CA.ORCID 0000-0002-0233-9361
Ayelet ZeremPediatric Neurology Institute, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Israel.ORCID 0000-0002-7923-4613
Marc EngelenDepartment of Child Neurology, Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Center, the Netherlands.ORCID 0000-0002-5346-8497
Fanny MochelINSERM U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau, ICM, France.ORCID 0000-0003-3970-3486
Funding
Leveraging Myelin-Sensitive Imaging to Predict Early Lesion Pathogenesis in Cerebral AdrenoleukodystrophyK23NS118044 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MALLACK, ERIC · 2021 to 2025
$970k
NINDS NIH HHS K23 NS118044
6 · The paper itself
Abstract
BACKGROUND AND
objectivesCerebral adrenoleukodystrophy (CALD) is a common manifestation of adrenoleukodystrophy (ALD) in men. Early detection of CALD lesions through MRI screening is critical to allow for therapeutic action preventing severe disability and death. While the frequency of brain MRI monitoring has been addressed by international recommendations, no consensus currently exists regarding which MRI sequences should be used in a real-world setting for screening and follow-up of CALD lesions. The aim of this study was to establish guidelines for the MRI protocol in clinical practice and to identify priority sequences for research use, thereby promoting intercenter harmonization.
methodsA modified Delphi procedure was used to achieve consensus on MRI protocols for ALD screening, lesion monitoring, and research applications among experts with experience in brain imaging in ALD. Questionnaires allowed experts to indicate whether they considered sequences as core, optional, or research, or to express agreement (5-point scale ranging from completely disagree to completely agree) with specific statements. Topics where no agreement was reached were discussed during online consensus meetings.
resultsThirty experts from 9 countries participated and agreed that the core screening protocol for ALD in adults and children should include at least 3D T1-weighted, spin-echo T2-weighted, 3D fluid-attenuated inversion recovery, and diffusion-weighted imaging (DWI). Postcontrast T1-weighted imaging should be performed systematically in specific clinical scenarios. Experts supported using DWI alongside the Loes score and postcontrast imaging to assess lesion progression. A research protocol was defined, prioritizing diffusion tensor imaging, MR perfusion, and quantitative volumetric analyses. DISCUSSION: This international project harmonizes the ALD MRI protocol, thus offering a practical framework to screen and monitor lesions, which will improve clinical decision making. It also identifies MRI sequences that should be prioritized in future research. Future research on MRI in ALD should focus on topics where no consensus has yet been reached in this project.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Use of Brain MRI in Cerebral Adrenoleukodystrophy: International Recommendations for Screening, Monitoring, and Research. · full record | OpenQuestion