Evidence map›Paper›PMID 41650345›Full record

ArticleBioconjugate chemistry2026

An Integrated NMR Approach for Evaluating Linker-Payload Conjugation with Monoclonal Antibodies.

Veronica Ghini, Sofia Siciliano, Leonardo Querci, Lorenzo Angiolini, Giuseppina Ivana Truglio, Elena Cini, Mario Piccioli, Elena Petricci, Paola Turano

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Veronica GhiniDepartment of Chemistry, University of Florence, via Della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.ORCID 0000-0003-3759-6701
Sofia SicilianoDepartment of Biochemistry, Chemistry and Pharmacy, via A. Moro 2, 53100 Siena, Italy.ORCID 0000-0003-1112-2540
Leonardo QuerciDepartment of Chemistry, University of Florence, via Della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
Lorenzo AngioliniDepartment of Biochemistry, Chemistry and Pharmacy, via A. Moro 2, 53100 Siena, Italy.ORCID 0009-0004-4024-6715
Giuseppina Ivana TruglioDepartment of Biochemistry, Chemistry and Pharmacy, via A. Moro 2, 53100 Siena, Italy.
Elena CiniDepartment of Biochemistry, Chemistry and Pharmacy, via A. Moro 2, 53100 Siena, Italy.ORCID 0000-0003-4420-8930
Mario PiccioliDepartment of Chemistry, University of Florence, via Della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.ORCID 0000-0001-9882-9754
Elena PetricciDepartment of Biochemistry, Chemistry and Pharmacy, via A. Moro 2, 53100 Siena, Italy.ORCID 0000-0002-9685-6342
Paola TuranoDepartment of Chemistry, University of Florence, via Della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.ORCID 0000-0002-7683-8614

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibody-drug conjugates (ADCs) are modern biopharmaceuticals that combine the therapeutic effects of small-molecule drugs with the outstanding selectivity of monoclonal antibodies (mAbs). Since their introduction in the biomedical field, research has focused on elucidating the structure, stability, and mode of action of ADCs. Nevertheless, standard characterization methods for ADCs heavily rely on disruptive techniques like mass spectrometry in a non-physiological environment. Here, we present an NMR approach combining

Indexed as

Antibodies, MonoclonalImmunoconjugatesTrastuzumabHumansMagnetic Resonance SpectroscopyAntibodies, MonoclonalImmunoconjugatesTrastuzumab

Identifiers

PMID41650345
PMCPMC12921666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.