Evidence map›Paper›PMID 41650278›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Indole-3-Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8-mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia.

Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen and 5 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Beibei WangDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Xu ChenDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Haowei XuDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhiqi ZengDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Keyu LuDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Yu MaoDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Qianru LvDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Hui ShiDepartment of Traditional Chinese Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Song LiuDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Xian ShenDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Chunyu YinDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Yang YangDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Yan GuoDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Xingyun WangGuangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-3156-5728
Rui ChengDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Funding

Jiangsu Province Association of Maternal and Child Health FYX202327National Natural Science Foundation of China 82171705National Natural Science Foundation of China 82371721National Natural Science Foundation of China 82571982Shanghai Rising-Star Program 22QB1401000
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) disrupts the process of alveolar development, characterized by damage to alveolar epithelial type II cells (AEC II). The present study aims to evaluate the impact of the tryptophan-derived metabolite indole-3-propionic acid (IPA) on postnatal pulmonary development in BPD. Metabolomics indicated that tryptophan metabolic dysfunction is associated with BPD, with IPA emerging as a key metabolite that co-varies at neonatal levels in both clinical and experimental BPD. Supplementation with IPA protected against hyperoxia-induced alveolar simplification, which was characterized by increased pro-proliferative, anti-apoptotic, and pro-transdifferentiation activities. Mechanistically, we evaluated circular dichroism (CD), molecular docking, surface plasmon resonance (SPR), and immunoprecipitation techniques, and speculated that IPA exerted its inhibitory effect on phosphorylation of vesicle associated membrane protein 8 (VAMP8) through direct molecular binding. This interaction influenced the assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex and subsequently promotes autophagosome-lysosome fusion. In summary, IPA alleviates hyperoxia-induced alveolar arrest by promoting autophagosome-lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.

Indexed as

Bronchopulmonary DysplasiaIndolesPulmonary AlveoliR-SNARE ProteinsAnimalsDisease Models, AnimalHumansRatsindolepropionic acidIndolesR-SNARE Proteinsapoptosisautophagybronchopulmonary dysplasiaindole‐3‐propionic acidSNARE complex

Identifiers

PMID41650278
PMCPMC13045412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.