Evidence map›Paper›PMID 41650276›Full record

ArticleScience advances2026

Animal-associated jumbo phages as widespread and active modulators of gut microbiome ecology and metabolism.

LinXing Chen, Antonio Pedro Camargo, Yiting Qin, Eugene V Koonin, Haoyu Wang, Yuanqiang Zou, Yi Duan, Hao Li

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The biology of jumbo phages.Nature communications · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

LinXing ChenState Key Laboratory of Advanced Environmental Technology, the Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei, China.ORCID 0000-0003-2774-1952
Antonio Pedro CamargoDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP 05508-060, Brazil.ORCID 0000-0003-3913-2484
Yiting QinState Key Laboratory of Advanced Environmental Technology, the Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei, China.ORCID 0009-0007-6168-701X
Eugene V KooninComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-3943-8299
Haoyu WangState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.ORCID 0000-0001-8236-3187
Yuanqiang ZouState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.ORCID 0000-0003-2380-264X
Yi DuanNational Key Laboratory of Immune Response and Immunotherapy, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Hao LiState Key Laboratory of Advanced Environmental Technology, the Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei, China.ORCID 0000-0001-8079-8881

Funding

Advanced analytics for uncovering virus dynamics and functional potentialU01DE034196 · NIDCR · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Nikos C Kyrpides · 2024 to 2026
$2.8M
NIDCR NIH HHS U01 DE034196
6 · The paper itself

Abstract

Huge phages are widespread in the biosphere, yet their prevalence and ecology in the human gut remain poorly characterized. Here, we report Jug (jumbo gut) phages with genomes of 360 to 402 kilobase pairs that comprise ~1.1% of the reads in human gut metagenomes, and are predicted to infect

Indexed as

BacteriophagesGastrointestinal MicrobiomeAnimalsBacteroidesGenome, ViralHumansMetagenomePhylogeny

Identifiers

PMID41650276
PMCPMC12880540

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.