Evidence map›Paper›PMID 41650263›Full record

ArticleScience advances2026

Antigen-specific T

Ines Sturmlechner, Abhinav Jain, Jingjing Jiang, Hirohisa Okuyama, Yunmei Mu, Maryam Own, Cornelia M Weyand, Jörg J Goronzy

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026
    Review
  2. Immune responses in aging adults.The Journal of clinical investigation · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ines SturmlechnerDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-1272-5618
Abhinav JainDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-6017-5492
Jingjing JiangDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Hirohisa OkuyamaDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0002-6019-6132
Yunmei MuDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Maryam OwnDepartment of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0003-7127-8392
Cornelia M WeyandDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2230-9802
Jörg J GoronzyDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-7670-1856

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
The NOTCH Signaling Pathway in Large Vessel VasculitisR01HL117913 · NHLBI · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 2014 to 2025
$5.0M
Oligoclonal T Cell Expansion &Rheumatoid ArthritisR01AR042527 · NIAMS · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 1993 to 2022
$4.8M
microRNA Regulation of T Cell SenescenceR01AI108891 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GORONZY, JORG J · 2014 to 2023
$4.6M
Telomere Damage Responses and Immune AgingR01AI108906 · NIAID · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 2014 to 2024
$4.0M
Influence of Age on CD4 T Memory CellsR01AG045779 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GORONZY, JORG J · 2013 to 2023
$4.0M
T Cell Immunity in Giant Cell ArteritisR01HL142068 · NHLBI · STANFORD UNIVERSITY · PI Cornelia M. Weyand · 2018 to 2026
$3.3M
Memory T Cell Development and Survival in T Cell Responses of Older IndividualsR01AI129191 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GORONZY, JORG J · 2017 to 2021
$1.9M
Mechanisms of genetic variants in TH2 autoimmunityR01AI184360 · NIAID · MAYO CLINIC ROCHESTER · PI JORG J GORONZY · 2024 to 2026
$1.8M
Mitochondrial Malfunction in T Cell Aging and Tissue InflammationU01AI179609 · NIAID · MAYO CLINIC ROCHESTER · PI Cornelia M. Weyand · 2024 to 2026
$1.7M
Postdoctoral Training Program for Research on AgingT32AG049672 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2016 to 2022
$1.3M
T cell surveillance of senescent cells under homeostasis and agingK99AG090620 · NIA · MAYO CLINIC ROCHESTER · PI Ines Sturmlechner · 2025 to 2026
$267k
NHLBI NIH HHS R01 HL117913NHLBI NIH HHS R01 HL142068NIAID NIH HHS R01 AI108891NIAID NIH HHS R01 AI108906NIAID NIH HHS R01 AI129191NIAID NIH HHS R01 AI184360NIAID NIH HHS U01 AI179609NIAID NIH HHS U19 AI057266NIAMS NIH HHS R01 AR042527NIA NIH HHS K99 AG090620NIA NIH HHS R01 AG045779NIA NIH HHS T32 AG049672
6 · The paper itself

Abstract

Older adults are susceptible to infections in part due to waning of immune memory. To uncover mechanisms of a long-lasting immune memory, we contrasted varicella zoster virus antigen-specific memory T cell responses in adults vaccinated at young (<20 years) or older age (>50 years) with a live-attenuated vaccine conferring durable protection only when given at young age or with an adjuvanted component vaccine eliciting long-lasting immunity in older adults. Unlike VZV-specific CD4

Indexed as

AgingAntigens, ViralTh17 CellsAdultAgedCD8-Positive T-LymphocytesHerpesvirus 3, HumanHumansImmunologic MemoryMiddle AgedVaccinationYoung AdultAntigens, Viral

Identifiers

PMID41650263
PMCPMC12880537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.