ArticleScience immunology2026
Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis.
Erratum issuedAbstract read
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Article in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- IL-17A-producing γδ T cells control pulmonary Mycobacterium abscessus infection in mice.Nature microbiology · 2026Article
- Genetic Association Between BTN3A1 Polymorphisms and the Risk of Rheumatoid Arthritis in a Chinese Population.International journal of rheumatic diseases · 2026Article
- UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation and predispose to intestinal inflammation.bioRxiv : the preprint server for biology · 2026Article
- γδ T Cells in Autoinflammatory Diseases.Cells · 2026Review
- Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis.Science immunology · 2026Article
- Perinatal γδ T cells: between invariance and diversity.Frontiers in immunology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
38 authors.
Lena S MayerDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-5158-7599
Jakob ArnoldDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0009-0004-0450-190X
Felix RoetteleDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Nadine ReuterDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ajinkya PattekarDepartment of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1416-1230
Takuya OhtaniInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0006-3876-4630
Mariana M RibeiroInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Rebecca SiwickiInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID 0000-0002-2061-3782
Kerstin BruderDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
David ObwegsDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0009-0009-0011-073X
Elin StahlDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0009-0001-2226-677X
Sarah BuechelDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3585-2743
Natascha RoehlenDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-6653-8765
Julia KolterInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3268-8124
Zohreh Mansoori MoghadamInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ahmed AlaswadCentre for Individualised Infection Medicine and TWINCORE, joint ventures between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.ORCID 0000-0003-1770-1332
Zhibek ZhumalidovaDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-3227-1692
Guang LiDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xinjuan LiuDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-7532-282X
Yang LiCentre for Individualised Infection Medicine and TWINCORE, joint ventures between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.ORCID 0000-0003-4022-7341
Amit SinghInstitute for Biomechanics, ETH Zürich, Zürich, Switzerland.ORCID 0000-0001-9979-7221
Jose Villacorta HidalgoCell and Gene Therapy (CGT) Research, Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany.ORCID 0000-0002-5028-3999
Maria D ParaskevopoulouTakeda Development Center Americas Inc., Cambridge, MA, USA.
Vijay YajnikTakeda Development Center Americas Inc., Cambridge, MA, USA.ORCID 0000-0001-6767-1712
Julius JuarezTakeda Development Center Americas Inc., Cambridge, MA, USA.
Yue RenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hongzhe LiDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
E John WherryInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0477-1956
James D LewisDepartment of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-3107-3862
Gary D WuDepartment of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1829-8795
Meenakshi BewtraDepartment of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6489-7043
Vesselin T TomovDepartment of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robert ThimmeDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Bertram BengschDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-2552-740X
Peter HasselblattDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-1107-6516
Simone PicelliInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.ORCID 0000-0002-1747-614X
Maike HofmannDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-8410-8833
SagarDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-8657-4704
Funding
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GARY D. WU · 1997 to 2026
$32.5MNIDDK NIH HHS P30 DK050306
Abstract
γδ T cells maintain intestinal immune homeostasis, but their contributions to human ulcerative colitis (UC) are poorly understood. We characterized γδ T cells in intestinal biopsies obtained from patients with UC and healthy donors using single-cell RNA sequencing, T cell receptor profiling, and mass cytometry. UC reduced CD103
Indexed as
Colitis, UlcerativeIntraepithelial LymphocytesReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsAdultFemaleHumansIntestinal MucosaMaleMiddle AgedSingle-Cell AnalysisReceptors, Antigen, T-Cell, gamma-delta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.