Evidence map›Paper›PMID 41650243›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Ufd2p promotes efficient crossover formation by destabilizing Top2p during meiosis.

Taicong Tan, Yanan Zhao, Yinghong Chen, Yali Mi, Jiaxin Zeng, Peng Du, Tingting Han, Yawen Liu, Ning Li, Jun Kong and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Structure and function of the synaptonemal complex.The Journal of cell biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Taicong Tan *Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.ORCID 0000-0001-7351-3788
Yanan Zhao *Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Yinghong Chen *Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.ORCID 0000-0003-2208-4105
Yali MiInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Jiaxin ZengInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Peng DuInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Tingting HanInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Yawen LiuInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Ning LiInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Jun KongInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Liying WangInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Yang YuInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Mulin Jun LiInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Liangran ZhangCollaborative Innovation Center of Cell Biology in Universities of Shandong, Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, China.ORCID 0000-0002-8550-6742
Wei LiInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.ORCID 0000-0002-6235-0749
Chao LiuInstitute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.ORCID 0000-0002-8844-0697

Funding

MOST | National Key Research and Development Program of China (NKPs) 2024YFC27066800 2022YFC2702600MOST | National Natural Science Foundation of China (NSFC) 32270898 32230029MOST | National Natural Science Foundation of China (NSFC) 32500060MOST | National Natural Science Foundation of China (NSFC) 32500751MOST | National Natural Science Foundation of China (NSFC) 82522037MOST | NSFC | National Science Fund for Distinguished Young Scholars (National Science Foundation for Distinguished Young Scholars) 81925015
6 · The paper itself

Abstract

Proper crossover (CO) formation in meiosis serves dual roles in ensuring accurate chromosome segregation and generating genetic diversity. However, the molecular mechanisms underlying CO number and distribution remain incompletely understood. Previous studies have implicated the ubiquitin-proteasome system in CO regulation, but specific regulators and mechanisms are poorly defined. Here, we identify the E3 ubiquitin ligase Ufd2p as a key regulator promoting efficient CO formation through a focused genetic screen in

Indexed as

Crossing Over, GeneticDNA Topoisomerases, Type IIMeiosisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitin-Protein LigasesAnimalsHumansMiceUbiquitinationDNA Topoisomerases, Type IISaccharomyces cerevisiae ProteinsTOP2 protein, S cerevisiaeUbiquitin-Protein Ligasescrossover interferencemeiotic recombinationTop2pubiquitin ligaseUfd2p

Identifiers

PMID41650243
PMCPMC12890856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.