ArticleProceedings of the National Academy of Sciences of the United States of America2026
Hydration gradients drive lipid self-segregation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Beyond Membrane Fluidity: Lipid Unsaturation and Hofmeister Cations Govern Nanoplastic Dynamics at Membrane Interfaces.Analytical chemistry · 2026Article
- Hydration gradients drive lipid self-segregation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Evaporation from a multicomponent aqueous mixture not only establishes a hydration gradient but may also lead to composition gradients in the other components. Here, we show that such a gradient induces a strong segregation between two phospholipids that differ only in the saturation of their acyl chains. Using high-resolution confocal Raman microscopy combined with small- and wide-angle X-ray scattering, we simultaneously resolve local composition and structure along the evaporation direction. We find that the saturated phospholipid, dipalmitoyl phosphatidylcholine (DPPC), accumulates near the air-liquid interface, while the unsaturated phospholipid, dioleoyl phosphocholine (DOPC), is displaced toward a more hydrated intermediate region, resulting in a complete inversion of their initial proportions. This nonmonotonic lipid gradient reflects the different water swelling capacities of the L
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