Evidence map›Paper›PMID 41650235›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Functional and antigenic constraints on the Nipah virus fusion protein.

Brendan B Larsen, Sheri Harari, Risako Gen, Cameron Stewart, David Veesler, Jesse D Bloom

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Brendan B LarsenBasic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Sheri HarariBasic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Risako GenDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0009-0004-4416-0417
Cameron StewartDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0000-0002-2786-6256
David VeeslerDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0000-0002-6019-8675
Jesse D BloomBasic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA 98109.ORCID 0000-0003-1267-3408

Funding

Project 5: mRNA and mRNA-launched nanoparticle vaccinesU19AI181881 · NIAID · UNIVERSITY OF WASHINGTON · PI KING, NEIL · 2024 to 2024
$41.1M
Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7M
Unraveling the bat humoral immune response against zoonotic viruses to guide the design of next-generation therapeuticsDP1AI158186 · NIAID · UNIVERSITY OF WASHINGTON · PI VEESLER, DAVID · 2020 to 2024
$5.4M
Prospectively characterizing the functional and antigenic effects of mutations to viral entry proteinsR01AI141707 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BLOOM, JESSE D · 2018 to 2022
$2.1M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1U19AI181881HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) DP1AI158186HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI141707NIAID NIH HHS 75N93022C00036NIAID NIH HHS DP1 AI158186NIAID NIH HHS R01 AI141707NIAID NIH HHS U19 AI181881
6 · The paper itself

Abstract

Nipah virus is a highly pathogenic virus in the family

Indexed as

Nipah VirusViral Fusion ProteinsAnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralHendra VirusHenipavirus InfectionsHumansMutationViral Envelope ProteinsVirus InternalizationAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralF protein, Nipah virusViral Envelope ProteinsViral Fusion Proteinsclass I fusion proteindeep mutational scanningparamyxoviruspseudovirus

Identifiers

PMID41650235
PMCPMC12885220

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.