Evidence map›Paper›PMID 41650224›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Structural analysis of rhodopsin states in megabody complexes.

David Salom, Diana S Suder, Wei Huang, Arum Wu, Els Pardon, Jan Steyaert, Philip D Kiser, Derek J Taylor, Shane Gonen, Krzysztof Palczewski

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David Salom *Department of Ophthalmology and Visual Sciences, Brunson Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0002-3208-1509
Diana S Suder *Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0002-6226-8390
Wei Huang *Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0003-2097-8148
Arum WuDepartment of Ophthalmology and Visual Sciences, Brunson Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0003-1038-7176
Els PardonStructural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, Belgium.ORCID 0000-0002-2466-0172
Jan SteyaertStructural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, Belgium.ORCID 0000-0002-3825-874X
Philip D KiserDepartment of Ophthalmology and Visual Sciences, Brunson Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0003-1184-9539
Derek J TaylorDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0001-9932-1856
Shane GonenDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0002-4829-3151
Krzysztof PalczewskiDepartment of Ophthalmology and Visual Sciences, Brunson Center for Translational Vision Research, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0002-0788-545X

Funding

STRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0M
NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2022 to 2026
$3.7M
Chemical Biology of the Visual PigmentsR01EY034519 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Philip David Kiser, Krzysztof Palczewski · 2023 to 2026
$2.0M
Breaking barriers in CryoEM through computational protein designR35GM142797 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GONEN, SHANE · 2021 to 2025
$1.9M
BLRD VA I01 BX004939BLRD VA IK6 BX006800European Strategy Forum on Research Infrastructures INSTRUCT-ERICHHS | NIH | National Eye Institute (NEI) EY034519 EY009339 EY034070HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35-GM142797NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY009339NEI NIH HHS R01 EY034519NIGMS NIH HHS R35 GM142797Research to Prevent Blindness (RPB) noneU.S. Department of Education (ED) GAANN; P200A210024U.S. Department of Veterans Affairs (VA) BX004939 BX006800
6 · The paper itself

Abstract

Rhodopsin, the most intensively studied G protein-coupled receptor (GPCR), is activated by light-induced isomerization of its chromophore 11-

Indexed as

RhodopsinAnimalsCryoelectron MicroscopyModels, MolecularProtein ConformationRhodopsinGPCRsnanobodyphototransductionrhodopsinvision

Identifiers

PMID41650224
PMCPMC12891041

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.