Evidence map›Paper›PMID 41650222›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A daily cycle of White Collar Complex dephosphorylation sustains circadian rhythmicity in

Bin Wang, Xiaoying Zhou, Jennifer J Loros, Jay C Dunlap

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Bin WangDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0002-0068-2887
Xiaoying ZhouDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Jennifer J LorosDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0003-0451-2858
Jay C DunlapDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0003-1577-0457

Funding

Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI MICHAEL L WHITFIELD · 2019 to 2026
$27.2M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Tools for Functional Analysis and Cell BiologyP01GM068087 · NIGMS · DARTMOUTH COLLEGE · PI SACHS, MATTHEW STEVEN · 2004 to 2013
$19.3M
Genetic and Molecular Dissection of the Neurospora ClockR35GM118021 · NIGMS · DARTMOUTH COLLEGE · PI Jay C. Dunlap · 2016 to 2026
$7.3M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) P01GM068087HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM113132HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM130454HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM118021NIGMS NIH HHS P01 GM068087NIGMS NIH HHS P20 GM113132NIGMS NIH HHS P20 GM130454NIGMS NIH HHS R35 GM118021
6 · The paper itself

Abstract

The transcription factor complex White Collar Complex (WCC) functions both as a photoreceptor and as the circadian positive element. In response to light, WCC acutely activates ~5% of all genes, whereas in the dark it influences expression of about 40% of the transcriptome. Among WCC targets is

Indexed as

Circadian RhythmDNA-Binding ProteinsFungal ProteinsNeurospora crassaTranscription FactorsGene Expression Regulation, FungalLightPhosphorylationPromoter Regions, GeneticDNA-Binding ProteinsFRQ protein, Neurospora crassaFungal ProteinsTranscription FactorsdephosphorylationFFCWC-1WC-2WCC activity

Identifiers

PMID41650222
PMCPMC12890800

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.