Evidence map›Paper›PMID 41649930›Full record

ArticleNutrition and health2026

Which over-the-counter herbal supplements are searched online? A review of internet trends, interest, and lithogenic potential of herbal health ingredients.

Sapna Thaker, Jo Huang, Karan N Thaker, Kien Tran, Parris Diaz, Tamara Keenum, John Knight, Kristina Penniston, Kymora B Scotland

Abstract read
In one paragraph

Article in Nutrition and health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sapna ThakerUniversity of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-6677-9489
Jo HuangDavid Geffen School of Medicine, Los Angeles, CA, USA.
Karan N ThakerUniversity of California Los Angeles, Los Angeles, CA, USA.
Kien TranUniversity of California Los Angeles, Los Angeles, CA, USA.
Parris DiazDepartment of Radiology, Stanford Medicine, Palo Alto, CA, USA.
Tamara KeenumUniversity of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0009-0005-4124-3177
John KnightUniversity of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-9683-8064
Kristina PennistonUniversity of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-6427-018X
Kymora B ScotlandDavid Geffen School of Medicine, Los Angeles, CA, USA.

Funding

Oxalobacter formigenes colonization and oxalate excretion in calcium oxalate kidney stone diseaseR01DK087967 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KNIGHT, JOHN · 2011 to 2020
$3.5M
NIDDK NIH HHS R01 DK087967
6 · The paper itself

Abstract

BackgroundWith the rise in availability of herbal supplements, there has been a similarly expanding landscape of online information about these supplements.Aims/ObjectivesThis study identifies commonly used herbal supplements, their ingredients, oxalate content, and the reliability of their online information.Methods/MethodologyA survey was administered to members of a nephrolithiasis Facebook group on their use of herbal supplements. The top 10 bestselling herbal supplements on Amazon and their common ingredients were identified. Consumer interest and online engagement with these ingredients were analyzed using Google Trends and BuzzSumo. The reliability of the top 10 articles for each ingredient was rated using the DISCERN questionnaire. Oxalate content was quantified by ion chromatography coupled with mass spectrometry.Results/FindingsThe most common ingredients in supplements were black pepper, ginger, apple cider vinegar, and turmeric. Google Trends identified apple cider vinegar, ginger, and turmeric as search terms of high interest. BuzzSumo revealed the highest article engagement and video views for apple cider vinegar. For all ingredients, average DISCERN scores for the most popular articles were in the "poor reliability" category. Turmeric-containing and standalone turmeric formulations were found to have the highest oxalate levels, with ranges of 2.69-54.8 mg/g and 15-19.5 mg/g, respectively.ConclusionsHigh consumer interest in herbal supplements combined with unreliable online information highlights the need for high-quality, evidence-based information. With popular herbal supplements containing varying amounts of oxalate, it may be useful for those providing care for kidney stone formers to familiarize themselves with popular herbal products and their lithogenic potential.

Indexed as

DISCERNherbalkidney stonesmisinformationnephrolithiasissocial media

Identifiers

PMID41649930
PMCPMC13235307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.