Evidence map›Paper›PMID 41649830›Full record

ArticleJAMA health forum2026

Human Papillomavirus Vaccination Policies and Discourse on Social Media.

Lanyue Zhang, Shouchuang Zhang, Siqi Liu, Weiyan Jian

Abstract read
In one paragraph

Article in JAMA health forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lanyue ZhangDepartment of Health Policy and Management, School of Public Health, Peking University, Beijing, China.
Shouchuang ZhangDepartment of Health Policy and Management, School of Public Health, Peking University, Beijing, China.
Siqi LiuAI Thrust, Information Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China.
Weiyan JianDepartment of Health Policy and Management, School of Public Health, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Cervical cancer remains a major public health challenge in China, and human papillomavirus (HPV) vaccine uptake remains far below the global average. Understanding public responses to national policy interventions is critical for promoting equitable vaccine access and uptake. Objective: To assess the association between 2 national HPV vaccination policies (August 2022 age expansion approval for HPV vaccination [policy 1] and January 2023 National Action Plan for Accelerating the Elimination of Cervical Cancer [policy 2]) in China and public discourse and engagement on social media. Design, Setting, and Participants: Cross-sectional study using interrupted time-series analysis of publicly available posts by individual users containing HPV-related and vaccine-related keywords from China's largest text-based social media platform collected between December 2021 and December 2024. Latent Dirichlet allocation topic modeling was used to identify 16 topics grouped into 5 thematic domains. Main Outcomes and Measures: Changes in the daily trends of public discussions across 5 thematic domains and 16 topics before and after policy implementation using interrupted time-series analysis. Results: This study analyzed 353 530 HPV-related posts on the social media platform from December 2021 to December 2024. Vaccine accessibility discussions initially increased following the age expansion policy (regression coefficient, 0.08; 95% CI, 0.05-0.12; P < .001). After the launch of the National Action Plan, discussions on the theme of vaccine accessibility decreased by 0.11 percentage points per day (95% CI, -0.14 to -0.08; P < .001). Conversely, discussions on awareness and knowledge increased by 0.04 percentage points per day (95% CI, 0.03-0.06; P < .001), as well as gender and sociocultural factors, which increased by 0.04 percentage points per day (95% CI, 0.02-0.06; P < .001). Conclusions and Relevance: These findings suggest that national HPV vaccination policies in China were associated with shifts in public discourse, including alleviated access concerns and increased health awareness and gender equity discussions. Social media data can provide timely insights into public responses to health interventions and inform strategies to promote equitable HPV vaccine uptake and cervical cancer elimination.

Indexed as

Health PolicyPapillomavirus InfectionsPapillomavirus VaccinesSocial MediaUterine Cervical NeoplasmsVaccinationChinaCross-Sectional StudiesFemaleHuman Papillomavirus VirusesHumansInterrupted Time Series AnalysisPapillomavirus Vaccines

Identifiers

PMID41649830
PMCPMC12881989

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.