Evidence map›Paper›PMID 41649787›Full record

ArticleInflammopharmacology2026

Anti-inflammatory, antioxidant, and antinociceptive properties of methanolic flower extracts of Tecoma stans: a promising natural therapeutic agent.

Abril Bernardette Martínez-Rizo, Oscar Isaac Correa-Polanco, Valeria García-Martínez, Fabiola Villa-de la Torre, Mario Alberto Ramírez-Camacho, Rocio Borges-Argáez, Eunice Yáñez-Barrientos, Alan Alexander Gonzalez-Ibarra, Angel Josabad Alonso-Castro, Claribel Huchin Chan and 1 more

Erratum issuedAbstract read
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In one paragraph

Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Abril Bernardette Martínez-RizoLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 x calle 90, Col. Inalámbrica, CP, 97069, Mérida, Yucatán, Mexico.ORCID http://orcid.org/0000-0002-8381-3730
Oscar Isaac Correa-PolancoLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 x calle 90, Col. Inalámbrica, CP, 97069, Mérida, Yucatán, Mexico.ORCID http://orcid.org/0009-0001-4348-0804
Valeria García-MartínezLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 x calle 90, Col. Inalámbrica, CP, 97069, Mérida, Yucatán, Mexico.ORCID http://orcid.org/0009-0002-2314-2688
Fabiola Villa-de la TorreLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 x calle 90, Col. Inalámbrica, CP, 97069, Mérida, Yucatán, Mexico.ORCID http://orcid.org/0009-0001-0663-3154
Mario Alberto Ramírez-CamachoCentro de Información de Medicamentos y Farmacia Clínica, Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.ORCID http://orcid.org/0000-0003-4152-3118
Rocio Borges-ArgáezUnidad de Biotecnología, Centro de Investigación Científica de Yucatán, Mérida, Yucatán, Mexico.ORCID http://orcid.org/0000-0002-4337-0031
Eunice Yáñez-BarrientosDivisión de Ciencias Naturales and Exactas, Universidad de Guanajuato, Guanajuato, Mexico.ORCID http://orcid.org/0000-0002-2626-1490
Alan Alexander Gonzalez-IbarraDepartment of Molecular Biology, Maria Curie- Skłodowska University, Lublin, Poland.ORCID http://orcid.org/0000-0003-3740-5055
Angel Josabad Alonso-CastroDivisión de Ciencias Naturales and Exactas, Universidad de Guanajuato, Guanajuato, Mexico.ORCID http://orcid.org/0000-0003-2660-8156
Claribel Huchin ChanLaboratorio de Análisis Clínicos de Servicio a la Comunidad, Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.ORCID http://orcid.org/0009-0002-6750-1291
Victor Ermilo Arana-ArgáezLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 x calle 90, Col. Inalámbrica, CP, 97069, Mérida, Yucatán, Mexico. victor.arana@correo.uady.mx.ORCID http://orcid.org/0000-0003-1434-1677

Funding

SECIHTI SECIHTI
6 · The paper itself

Abstract

introductionTecoma stans (T. stans) is traditionally employed in folk medicine for the management of inflammatory conditions; however, its pharmacological properties and underlying mechanisms of action remain insufficiently characterized.

aimThis study aimed to evaluate the anti-inflammatory, antioxidant, and cytoprotective effects of the methanolic flower extract of T. stans using both in vitro and in vivo models, with particular emphasis on cytokines, modulation, oxidative stress markers, and lipid-derived inflammatory mediators. METHODOLOGY: Cytotoxicity and hemotoxicity were assessed using MTT reduction and hemolysis assays, respectively. Anti-inflammatory activity was evaluated employing carrageenan-induced paw oedema and xylene-induced ear oedema models. Modulation of cytokine (TNF-α, IL-1β, IL-6, IL-10) was determined in both in vivo and in vitro models. Additionally, the effects of the extract on nitric oxide (NO), hydrogen peroxide (H

resultsT. stans extract exhibited no cytotoxic or hemolytic effects, maintaining cell viability above 90%. It significantly attenuated inflammatory responses in edema models, reduced pro-inflammatory cytokines and mediator levels, and increased IL-10 production. Furthermore, the extract markedly decreased NO and H

conclusionsThese findings support the anti-inflammatory and antioxidant potential of T. stans, mediated through cytokine modulation, attenuation of oxidative stress, and partial inhibition of COX/LOX pathways. Collectively, its pharmacological profile highlights its potential as a natural therapeutic agent for the management of inflammatory disorders.

Indexed as

AnalgesicsAnti-Inflammatory AgentsAntioxidantsFlowersPlant ExtractsAnimalsCytokinesEdemaHumansInflammationMaleMethanolMiceNitric OxideOxidative StressRatsAnalgesicsAnti-Inflammatory AgentsAntioxidantsCytokinesMethanolNitric OxidePlant ExtractsAntiinflammatory activityAntioxidantCytotoxic effectsPharmacological propertiesTecoma stans

Identifiers

PMID41649787

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.