ArticleEJNMMI radiopharmacy and chemistry2026
A new
Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
16 authors.
Funding
Abstract
backgroundFibroblast activation protein (FAP) has emerged as a critical biomarker in the tumor microenvironment of various cancers. Radioligands targeting FAP have shown promise for cancer theranostics. To advance cancer imaging, we synthesized a dimeric radioligand based on a 4-quinolinoyl-glycyl-2-cyanopyrrolidine scaffold and conducted studies in cells and mouse tumor models to evaluate its target-binding affinity and PET imaging performance.
resultsOncoFAP, a commercially available FAP ligand, was conjugated via amide coupling with 1,4-butanediamine to generate a monomeric intermediate, hmFAP
conclusionshmFAP
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Registered trials
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