Evidence map›Paper›PMID 41649684›Full record

ReviewCrop health2025

RALF-FER, a master ligand‒receptor pair in plant health.

Xing-Yan Chen, Jia Chen, Fan Xu, Xin-Zhong Cai

Abstract readReview
In one paragraph

Review in Crop health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xing-Yan ChenZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China.
Jia ChenHunan Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan University, Changsha, China.
Fan XuZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China. fan_xu@zju.edu.cn.
Xin-Zhong CaiZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, 310058, China. xzhcai@zju.edu.cn.

Funding

Hainan Provincial Natural Science Foundation of China 324CXTD430National Natural Science Foundation of China 31871947Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding 2021C02064
6 · The paper itself

Abstract

Pathogens deliver many effector proteins into the plant apoplast, which helps plants evade pattern recognition receptor (PRR)-mediated surveillance by camouflaging or blocking PRR-triggered signaling. Plants must prioritize immunity or growth and development according to the presence or absence of pathogen-derived effectors. Crosstalk exists between PRR immune signaling pathways and growth and development pathways. A typical example is the signaling pathway of the receptor kinase FERONIA (FER), a core element of a global signaling network. FER interacts with its coreceptors and different Rapid Alkalinization Factor (RALF) peptide ligands to function in various growth and developmental processes and respond to pathogens. Studies on the roles of host FERs in different plant species and those of RALFs derived from both hosts and pathogens are beginning to flourish. Here, we focus on recent advances in FER and RALF in plant‒pathogen interactions, with an emphasis on the mechanisms underlying these interactions. We also present a brief outlook to highlight challenges and perspectives for future research on how to utilize the RALF-FER pair or its related signaling elements as targets to improve crop resistance to pathogens.

Indexed as

Crop resilienceFERONIAPathogenPlant immunityRALF

Identifiers

PMID41649684
PMCPMC12807370

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.