SynthesisPediatric nephrology (Berlin, Germany)2026
Prevalence of HIV-associated nephropathy in children: a systematic review with meta-analysis of studies published between 2004 and 2019.
Synthesis in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDespite major advances in antiretroviral therapy, HIV infection remains a significant global public health challenge. HIV can directly affect the kidneys, leading to HIV-associated nephropathy in children, a condition characterized by proteinuria, elevated serum creatinine, and kidney enlargement. HIV-associated nephropathy is a serious complication that may progress to kidney failure and death.
objectiveTo estimate the prevalence of HIV-associated nephropathy in children.
methodsWe searched PubMed, Embase, LILACS, SciELO, and Web of Science for relevant studies. Searches used the terms "AIDS-associated nephropathy" AND "child."
resultsA total of 1,181 records were identified, of which 10 studies (n = 1,136 children living with HIV) met inclusion criteria. Most included studies were conducted before widespread ART availability and used proteinuria as a proxy for HIV-associated nephropathy. The pooled prevalence of HIV-associated nephropathy was 17% (95% CI, 8%-31%; I
conclusionHIV-associated nephropathy was historically a common and life-threatening complication among children living with HIV. However, the available evidence is largely based on studies conducted more than a decade ago and often relied on proteinuria rather than biopsy-confirmed diagnosis.
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