Evidence map›Paper›PMID 41649489›Full record

ArticleACS sensors2026

Hyperpolarized

Eni Minerali, Mai T Huynh, Hyejin Park, Jun Chen, Sasanka Wathukara Dewege, Joseph Park, Zohreh Erfani, Michael E Chirgwin, Emily R Derbyshire, Jae Mo Park and 1 more

Erratum issuedAbstract read
In one paragraph

Article in ACS sensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Complementary hyperpolarizedNpj imaging · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Eni MineraliDepartment of Chemistry, Duke University, Durham, North Carolina 27705, United States.
Mai T HuynhAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.ORCID 0000-0002-5545-2464
Hyejin ParkDepartment of Chemistry, Duke University, Durham, North Carolina 27705, United States.ORCID 0000-0003-0687-0114
Jun ChenAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Sasanka Wathukara DewegeAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Joseph ParkAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Zohreh ErfaniAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.ORCID 0000-0002-6754-5684
Michael E ChirgwinDepartment of Chemistry, Duke University, Durham, North Carolina 27705, United States.ORCID 0000-0002-2244-3473
Emily R DerbyshireDepartment of Chemistry, Duke University, Durham, North Carolina 27705, United States.ORCID 0000-0001-6664-8844
Jae Mo ParkAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.ORCID 0000-0002-7404-6971
Qiu WangDepartment of Chemistry, Duke University, Durham, North Carolina 27705, United States.ORCID 0000-0002-6803-9556

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
Development of early metabolic imaging biomarkers for muscular dystrophy and cardiomyopathy in patientsR01HL170039 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI PRADEEP P.A. MAMMEN, Jae Mo Park · 2024 to 2026
$2.2M
A Clinical MR Scanner for Imaging Hyperpolarized Carbon-13S10RR029119 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2011 to 2011
$2.2M
A liquid helium-free preclinical polarizer for hyperpolarized 13C metabolic imagingS10OD028490 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI WANSAPURA, JANAKA · 2020 to 2020
$600k
Developing Hyperpolarized Nitrogen-15 MRI Agents for Probing Glutamine MetabolismR21EB036580 · NIBIB · DUKE UNIVERSITY · PI Qiu Wang · 2025 to 2026
$449k
Probing Hyperpolarized 15N2-diazirine as A Universal Molecular Tag in MRIR21EB024824 · NIBIB · DUKE UNIVERSITY · PI WANG, QIU · 2018 to 2019
$427k
NCRR NIH HHS S10 RR029119NHLBI NIH HHS R01 HL170039NIBIB NIH HHS R21 EB024824NIBIB NIH HHS R21 EB036580NIDDK NIH HHS P30 DK127984NIH HHS S10 OD028490NINDS NIH HHS R01 NS107409
6 · The paper itself

Abstract

The enzyme γ-glutamyl transferase (GGT) plays an important role in redox homeostasis and is overexpressed in many different cancers. The ability to assess GGT activity provides critical insights into cancer prognosis and pathology. Here, we present a novel imaging agent, (

Indexed as

gamma-GlutamyltransferaseMagnetic Resonance ImagingAnimalsKidneyNitrogen IsotopesRatsgamma-GlutamyltransferaseNitrogen-15Nitrogen Isotopes(15N)2-diazirine15N MRI agentd-DNPlong T1γ-glutamyl transferase

Identifiers

PMID41649489
PMCPMC13019318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.