Evidence map›Paper›PMID 41649478›Full record

ArticleeLife2026

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency.

Yuji Miyatake, Takeshi Kamakura, Tomokatsu Ikawa, Ryo Yanagiya, Ryutaro Kotaki, Kazuaki Kameda, Ryo Koyama Nasu, Kazuki Okuyama, Ken-Ichi Hirano, Hiroyuki Hosokawa and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yuji Miyatake *Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan.
Takeshi Kamakura *Department of Regulation of Infectious Cancer, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0009-0002-4523-8971
Tomokatsu IkawaDivision of Immunology and Allergy, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan.
Ryo YanagiyaDepartment of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan.
Ryutaro KotakiDepartment of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan.
Kazuaki KamedaDepartment of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan.ORCID https://orcid.org/0000-0001-8418-5118
Ryo Koyama NasuDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kazuki OkuyamaLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Ken-Ichi HiranoDepartment of Immunology, Tokai University School of Medicine, Isehara, Japan.ORCID https://orcid.org/0000-0003-3495-610X
Hiroyuki HosokawaDepartment of Immunology, Tokai University School of Medicine, Isehara, Japan.ORCID https://orcid.org/0000-0002-9592-2889
Katsuto HozumiDepartment of Immunology, Tokai University School of Medicine, Isehara, Japan.ORCID https://orcid.org/0000-0002-7685-6927
Masato OhtsukaDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan.
Takahiro KisikawaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Chikako ShibataDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Motoyuki OtsukaDepartment of Gastroenterology and Hepatology, Okayama University Hospital, Okayama, Japan.
Reo MaruyamaProject for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Kiyoshi AndoHematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Tomohiro KurosakiLaboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0002-6352-304X
Hiroshi KawamotoLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Ai KotaniDepartment of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan.ORCID https://orcid.org/0000-0002-0976-8687

Funding

Japan Agency for Medical Research and Development 22ama221213Japan Agency for Medical Research and Development 22ama221215Japan Science and Technology Agency JPMJCR19H5Japan Society for the Promotion of Science JP20H03716Japan Society for the Promotion of Science JP20K17362
6 · The paper itself

Abstract

Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 (

Indexed as

B-LymphocytesCell DifferentiationLymphopoiesisMicroRNAsTrans-ActivatorsAnimalsAntigens, CD19Forkhead Box Protein O1Forkhead Transcription FactorsHematopoietic Stem CellsMicePhosphorylationAntigens, CD19CD19 antigen, mouseEbf1 protein, mouseForkhead Box Protein O1Forkhead Transcription FactorsFoxo1 protein, mouseMicroRNAsTrans-ActivatorsB cell developmentEBF1FOXO1immunologyinflammationMir195mouse

Identifiers

PMID41649478
PMCPMC12880805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.