Evidence map›Paper›PMID 41649399›Full record

ArticleJournal of biomechanical engineering2026

In-Vitro Evaluations of Shape Memory Polymer Scaffolds With Tunable Architecture for the Endovascular Embolization of Unruptured Intracranial Aneurysms.

Tanner L Cabaniss, Geoffrey Colby, Yingtao Liu, Hyowon Lee, Bradley N Bohnstedt, Chung-Hao Lee

Abstract read
In one paragraph

Article in Journal of biomechanical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tanner L CabanissSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019.
Geoffrey ColbyDepartment of Neurosurgery, University of California, Los Angeles , Los Angeles, CA 90095.
Yingtao LiuSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019.
Hyowon LeeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907.
Bradley N BohnstedtDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN 46202.
Chung-Hao LeeBiomechanics and Biomaterials Design Laboratory (BBDL), Department of Bioengineering, University of California, Riverside , Riverside, CA 92521.

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI TIMOTHY M VANWAGONER · 2013 to 2026
$68.2M
Improving outcomes in endovascular treatment of intracranial aneurysms: Combining additive manufacturing, in-silico modeling, and shape memory polymersR01HL159475 · NHLBI · UNIVERSITY OF OKLAHOMA · PI Chung-Hao Lee · 2022 to 2026
$3.3M
NHLBI NIH HHS R01 HL159475NHLBI NIH HHS R01HL159475NIGMS NIH HHS U54 GM104938Oklahoma Center for the Advancement of Science and Technology HR18-002
6 · The paper itself

Abstract

Translationally relevant metrics for shape memory polymer (SMP) scaffolds intended for the endovascular treatment of intracranial aneurysms were evaluated in various in vitro experiments. Multiple SMP formulations were first evaluated for glass transition properties, with saturated scaffolds demonstrating Tg midpoints of 39 °C, 35 °C, and 32 °C, respectively. Then, the scaffold's porosity (85-95%) and infill pattern (rectilinear, honeycomb, gyroid) were varied, and these designs were systematically compared by compressibility, shape recovery (SR), and pulsatile compaction resistance. The compressibility of ideal and wide-necked aneurysm geometries, each in 6 mm and 8 mm diameter sizes, indicated an upper limit of ∼9 mm in treatable aneurysm diameter for a 5 French catheter. Under physiologically relevant pulsatile loading, all scaffold designs resisted notable compaction, with maximum deformation values not exceeding 55 μm. The shape recovery forces were primarily governed by the porosity level, with low- and medium-porosity scaffolds showing complete and reliable shape recovery, and high-porosity scaffolds exhibiting reduced completeness of shape recovery. Shape recovery rates varied both within and across infill pattern and porosity groups. Together, these findings provide quantitative benchmarks for the translational viability of our SMP scaffold in different key stages of device deployment and establish design guidelines for further optimization of patient-specific endovascular devices.

Indexed as

Embolization, TherapeuticEndovascular ProceduresIntracranial AneurysmMechanical PhenomenaPolymersSmart MaterialsTissue ScaffoldsMaterials TestingPorosityPolymersSmart Materials3D printingcerebral aneurysmsintrasaccular occlusionshape memory polymerstissue scaffolds

Identifiers

PMID41649399
PMCPMC12890180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.