ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Bone marrow adipose tissue: fueling breast cancer bone metastasis via pro-tumor mechanisms and novel therapeutic targets.Clinical & experimental metastasis · 2026Review
- Chemokine-Driven Intercellular Crosstalk in the Osteosarcoma Microenvironment After Neoadjuvant Chemotherapy: A Single-Cell RNA Sequencing Study.Biomedicines · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Bone is the most common destination of metastatic breast cancer cells. Upon dissemination to the bone, cancer cells may either colonize aggressively or enter a quiescent state, depending on interactions with the bone microenvironment. This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in the bone marrow. Cancer cells remain quiescent as disseminated tumor cells (DTCs) or as micrometastases within an inactive osteoblastic microenvironment (homeostasis) but colonize the bone in an active, nonmineralized osteoblastic (osteogenic) microenvironment. In a highly mineralized osteoblastic microenvironment, basal-like tumor cells remain quiescent, whereas luminal-like cancer cells survive and invade the bone. These findings provide a comprehensive explanation for the divergent outcomes of disseminated cancer cells in the bone, focusing on whether they colonize, reside in quiescence, or reactivate from dormancy. Moreover, in a supportive osteogenic microenvironment, both cancer cells and well-differentiated osteoblasts were demonstrated to activate osteoclasts, leading to osteolytic lesions. Cellular (osteoblasts) and matrix (bone matrix) components exhibited distinct roles in bone colonization. Furthermore, the therapeutic potential of disrupting integrin-mediated interactions between tumor cells and the bone matrix was evaluated in animal experiments to prevent the reactivation of quiescent tumor cells and their colonization of the bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.