Evidence map›Paper›PMID 41648870›Full record

ArticleIntestinal Failure (New York, N.Y.)

Long term outcomes of no gut syndrome in children - A multicentre study.

Elena Cernat, Susan Hill, Rachel Wood, Assad Butt, Sally Buxton, Jeng Cheng, Jenny Goldthorpe, Jonathan Hind, Jutta Koglmeier, Nkem Onyeador and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Intestinal Failure (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elena CernatPaediatric Gastroenterology Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Susan HillPaediatric Gastroenterology Department, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Rachel WoodDepartment of Therapy and Dietetics, Royal Manchester Children's Hospital, Manchester, UK.
Assad ButtPaediatric Gastroenterology Department, Royal Alexandra Children's Hospital, Brighton, UK.
Sally BuxtonPaediatric Gastroenterology Department, Great North Children's Hospital, Newcastle, UK.
Jeng ChengPaediatric Gastroenterology Department, Alder Hey Children's Hospital, Liverpool, UK.
Jenny GoldthorpePaediatric Gastroenterology Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Jonathan HindPaediatric Liver, GI and Nutrition Centre, King's College Hospital, London, UK.
Jutta KoglmeierPaediatric Gastroenterology Department, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Nkem OnyeadorPaediatric Gastroenterology Department, St George's Hospital NHS Foundation Trust, London, UK.
Sue ProtheroePaediatric Gastroenterology Department, Birmingham Children's Hospital, Birmingham, UK.
Sunita RajaniPaediatric Gastroenterology Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
Catherine RichardsDepartment of Paediatric Surgery, Evelina London Children's Hospital, London, UK.
Camilla SalvestriniPaediatric Gastroenterology Department, Addenbrooke's Hospital, Cambridge, UK.
Chris SmithDepartment of Nutrition and Dietetics, Royal Alexandra Children's Hospital, Brighton, UK.
Arun UrsPaediatric Gastroenterology Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
Akshay BatraPaediatric Gastroenterology Department, Southampton Children's Hospital, Southampton, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Children with extreme short bowel syndrome, including those who have undergone resection of the entire jejunum and ileum-termed "No Gut Syndrome" (NGS) in the adult literature-are now surviving due to advancements in parenteral nutrition (PN) and medical care. This study aims to describe the population characteristics and long-term outcomes of children with NGS. Material and methods: A questionnaire was distributed to the paediatric intestinal failure (IF) centres in the UK to identify patients with NGS discharged home on PN. Inclusion criteria: infants/children < 18 years with duodenum plus up to 5 cm jejunum and colon (total/partial). Follow-up data was collected two years after the initial recruitment. A multicentre Health Research Authority approval was obtained. Results: 19/20 (95 %) IF centres managing 379 HPN patients responded - 27/379 (7 %) had ultrashort-bowel syndrome (U-SBS) and an additional 14/379 (4 %) NGS. Aetiology of NGS was - midgut volvulus (64 %), bowel ischaemia (22 %), necrotising enterocolitis (7 %), jejuno-ileal atresia (7 %).Nine patients had a colonic remnant in continuity. Thirteen/14 patients (93 %) remained stable on PN with one weaned off following small bowel transplant. Nine/13 (69 %) patients received > 80 % of EAR as PN and 4/13 (31 %), 30-80 %. Eight/13 (61 %) tolerated some form of enteral nutrition. There were no deaths during the follow-up period. Educational outcomes were positive showing that 11/14 (79 %) are attending school, 2/14 (14 %) nurseries with 1 awaiting enrollment (7 %). Conclusion: Advances in PN and health care have improved the long-term survival of patients with NGS. In addition, these children are attending school and participating in daily activities without significant limitation.

Indexed as

Intestinal failureNo gut syndromePaediatricsParenteral nutritionShort bowel syndrome

Identifiers

PMID41648870
PMCPMC12851213

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.